Compound and method for treating skin for acne or psoriasis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 94, 546 95, 548160, 548180, 556 9, 556407, 556437, 556438, 558414, 558433, 564 88, 564169, 564217, 514 63, 514367, 514477, 514478, 514490, 514492, 514514, 514520, 514502, 514521, 514522, 514529, 514533, 514859, 514863, A61K 3121, A61K 3124, C07D45506, C07D27762, C07F 704

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active

050860607

ABSTRACT:
The effects of acne and psoriasis are relived by applying either topically or by oral adminstration, a compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of H, Cl, straight or branched alkyl of 1 to 10 carbon atoms, NO.sub.2, COOR.sub.6, CN, OR.sub.6, NR.sub.6 R.sub.7, NR.sub.6 C(.dbd.S)NR.sub.7 R.sub.8, NF.sub.6 COR.sub.7, SO.sub.2 NR.sub.6 R.sub.7, CH(CH.sub.3)COOH, CONR.sub.6 R.sub.7, COR.sub.6, OCONR.sub.6 R.sub.7, NR.sub.6 COONR.sub.7, R.sub.9 OR.sub.6, NR.sub.6 SO.sub.2 R.sub.7, Si(CH.sub.3).sub.3, and NR.sub.6 CONR.sub.7 R.sub.8,

REFERENCES:
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patent: 4877805 (1989-10-01), Kligman
patent: 4888342 (1989-12-01), Kligman
Straumfjord, M. D., Acne, pp. 219-225 (1943).
South-East Scotland Faculty of the College of General Practioners, British Medical Journal, p. 294 (1963).
Lynch et al., Archives of Dermatology and Syphilology (1947) pp. 355, 357.
Mitchell et al., Archive of Dermatology and Syphilology (1951) pp. 428-430.
Stuttgen et al., Dermatologica, 124, 65-80 (1962).
Harmes et al., Acta. Derm Venereol (Stockh) 1986, 66, 149-154.
Mezick et al., The Journal of Investigative Dermatology 83, 110-113 (1984).
J. A. D. Anderson et al., Brit. Med. J. 2, 294-296 (1963).
Von. P. Beer, Dermatologics, 124; 192-195 (1962).

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