Compound 2-iodo-2'-deoxyadenosine

Details Compound 2-iodo-2'-deoxyadenosine Compound 2-iodo-2'-deoxyadenosine

1986-06-27

1988-01-12

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1916

Patent

active

047192950

ABSTRACT:
Nucleotide and nucleoside compounds are provided, namely 2-halo-2'-deoxyadenosine 5'-phosphate compounds (I) especially as the monosodium and disodium salt, and 2-iodo-2'-deoxyadenosine (II); as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds of the invention have pharmacological properties and are useful antimicrobial agents, antiviral agents, and antileukemic agents. ##STR1##

REFERENCES:
patent: 3201389 (1965-08-01), Fujimoto et al.
patent: 3337529 (1967-08-01), Laufer
Carson et al., I, Proc. Nat. Acad. Sci. USA, vol. 77(11), pp. 6865-6869, 1980.
Carson et al., II, Blood, vol. 62(4), pp. 737-743, 1983.
Huang et al, Chem. Abstr., 100:210318u, Jun. 18, 1984.
Bennett et al, Chem. Abstr., 103:31970r, Aug. 5, 1985.

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