Compositions with vascular damaging activity

Details Compositions with vascular damaging activity Compositions with vascular damaging activity

2006-09-12

2006-09-12

Richter, Johann (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C558S197000, C558S210000

Reexamination Certificate

active

07105501

ABSTRACT:
Compositions for the inhibition of the formation of new vaculature by angiogenesis are provided as in compounds which are salts comprising as an acidic component a compound of formula (1) wherein: R1, R2and R3are each independently alkyl, R4is alkoxy, haloalkoxy, alkyl, haloalkyl, alkenyl, alkynyl, alkylthio, alkylsulphinyl, alkylsulphonyl, hydroxy or halo, R5is hydrogen, alkoxy, alkyl, alkylthio, hydroxy, phosphate or halo, and, as the basic component, a compound selected from the group consisting of (2) a compound of formula (2) wherein R6is hydrogen or alkyl R7is alkyl, alkylamino, dialkylamino, nitroamino, hydrazine, mercapto or alkylthio X is CH2, CH2CH2, CH2S, CH2CH2S Y is NH or S or a compound of formula (3) wherein R8is alkyl or aminoalkyl R9is hydrogen, alkyl or optionally substituted phenyl or, a compound of formula (4) wherein Z is O, S, CH2, CHR13 or a bond R10, R11, R12and R13are each independently alkyl or hydrogen or, a compound of formula (5) wherein R14is alkyl and the pharmaceutically acceptable solvates and hydrates thereof.

REFERENCES:
patent: 4996237 (1991-02-01), Pettit et al.
patent: 5430062 (1995-07-01), Cushman et al.
patent: 5554638 (1996-09-01), Dewhirst et al.
patent: 5561122 (1996-10-01), Pettit
patent: 6670334 (2003-12-01), Venit et al.
patent: 92/16486 (1992-10-01), None
patent: 9935150 (1999-07-01), None
patent: 00/48606 (2000-08-01), None
patent: 01/12579 (2001-02-01), None
Pettite George, et al., Anti-neoplastic agents 463. Synthesis of Combretastatin A-3 diphosphate prodrugs, Anti-Cancer Drug Design (2001), Volume Date 2000, 15(6), 397-403.
Tozer et al., Combrestastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues, “Cancer Research”, 59, pp. 1626-16234, 1999.
Bedford, S. B. et al. “Synthesis of Water-Soluble Prodrugs of the Cytotoxic Agent Combretastatin A4.” Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 2 (1996) pp 157-160.
Tozer, G. M., et al. “Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent . . . ” Cancer Research, vol. 59, No. 7 (1999) pp. 1626-1634.
Pettit, G. R., et al. “Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs.” Anti-Cancer Drug Design, vol. 15, No. 3 (2000) pp. 203-216.

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