Compositions with controlled zero-order delivery rate and method

Details Compositions with controlled zero-order delivery rate and method Compositions with controlled zero-order delivery rate and method

1990-08-20

1993-06-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424479, 424480, 424493, 424494, A61K 954, A61K 962

Patent

active

052195759

ABSTRACT:
The present invention relates to compositions having a controlled zero-order delivery rate of the active component. The composition comprises a core or a protective layer coated with a continuous matrix of constant composition containing such a mixture of active substance(s) and excipient(s) that the concentration of the active substance(s) decreases from the core or the protective layer towards the outside, and the concentration of the excipient(s) increases in the same direction, whereas the sum of two substantially remains constant over the whole distance.

REFERENCES:
patent: 4289795 (1981-09-01), Bogentoft et al.
patent: 4341759 (1982-07-01), Bogentoft et al.
patent: 4457907 (1984-07-01), Porter
patent: 4624848 (1986-11-01), Lee
patent: 4749576 (1988-06-01), Lee

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