Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-06-07
1996-12-24
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514171, 514549, 514552, 514671, A61K 31685, A61K 3156, A61K 3122, A61K 3123, A61K 3113
Patent
active
055873669
ABSTRACT:
Treatment and prophylaxis of endotoxin caused toxicity is disclosed. This is accomplished by administering phospholipid containing compositions to the subject. The compositions are protein and peptide free, and may contain triglycerides, or other polar or neutral lipids.
REFERENCES:
patent: 4818537 (1989-04-01), Guo
patent: 5376452 (1994-12-01), Hope et al.
Schwarzenberg, et al, "Ursodeoxycholic Acid Modifies Gut-Derived Endotoxemia In Neonatal Rats", Ped. Res. 35(2):214-217 (1994).
Calmus, et al, "Differential Effects of Chenodeoxycholic and Ursodeoxycholic Acids on Interleukin 1, . . ." Hepatology 16(3):719-723 (1992).
Pain, et al, "Prevention of Postoperative renal dysfunction in patients with obstructive jaundice: a multicentre study of bile salts and lactulose", Br. J. Surg. 78:467-469 (1991).
Greve, et al, "Bile Acids Inhibit Endotoxin--Induced Release of Tumor Necrosis Factor By Monocytes: An In Vitro Study", Hepatology 10(4):454-458 (1989).
Cahill, et al, "Bile Salts, Endotoxin And Renal Function In Obstructive Jaundice", Surg. Gynec. & Obstet. 165:519-522 (Dec. 1987).
Thompson, et al, "A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice", Br. J. Surg. 73:634:636 (1986).
Hoffman, "Chemistry and Enterohepatic Circulation of Bile Acids", Hepatology 4(5):4S-14S (1984).
Bertok, "Physico-Chemical Defense of Vertebrate Organisms: The Role of Bile Acids in Defense Against Bacterial Endotoxins", Persp. Biol. And Med. 1977:70-75 (Autumn 1977).
Kocsar, et al., "Effect of Bile Acids on the International Absorption of Endotoxin in Rats", J. Bacteriol 100(1):220223 (1969).
Ribi, "Reaction of Endotoxin and Surfactants", J. Bacteriol 92(5):1493-1509 (1966).
Facts and Comparisons, Maz 1992, p. 40.
Gordon Bruce R.
Levine Daniel M.
Parker Thomas S.
Rubin Albert L.
Saal Stuart D.
Jordan Kimberly
The Rogosin Institute
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