Compositions useful for the treatment of pathologies...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

06897235

ABSTRACT:
This invention features the use of the spirolaxine of formula (I) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the Type 2 insulin-resistant diabetes. This invention also features a pharmaceutical composition in which the spirolaxine of formula (I) acts as active principle in association with the all-trans retinoic acid of formula (II) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the acute malignant haemopathies.

REFERENCES:
patent: WO 0050414 (2000-08-01), None
patent: WO 0168070 (2001-09-01), None
Patent Abstracts of Japan, vol. 1998, No. 05, Apr. 30, 1998 & JP 10-007557 A (Banyu Pharmaceut Co., Ltd.) Jan. 13, 1998.
Database WPI, Section Ch, Week 199601, Derwent Publications Ltd., London GB; AN 1996-006892, XP002223650 & JP 07 285862 A (Kokka Iyaku Kanrikyoku Shikawa Kokinso) Oct. 31, 1995.
Visant et al.; “All-Trans Retinoic Acid Potentiates Megakaryocyte Colony Formation: In Vitro and In Vivo Effects after Administration to Acute Promyelocytic Leukemia Patient,” Leukemia, Macmillan Press Ltd., vol. 8, No. 12, Dec. 1994, pp. 2183-2187.
Yasuhiro et al., Database Biosis Online!, Biosciences Information Service, “Inhibition of Growth and Induction of Apoptosis by All-Trans Retinoic Acid in Lymphoid Cell Lines Transfected with the PML/RAR-Alpha Fusion Gene”, Database Accession No. PREV199699105088 XP002223648.
Findley et al., “Effect of Retinoic-Acid on the Clonal Growth of Childhood Myeloid and Lymphoid Leukemias a Pediatric Oncology Group Study”, Database Biosis Online!, Biosciences Information Service, Philadelphia, PA, 1984, Database Accession No. PREV198579069170 XP002223649.
Shappell et al., 15S-Hydroxyeicosatetranenoic Acid Activates Peroxisome Proliferator-Activated Receptor Gamma and Inhibits Proliferation in PC3 Prostate Carsinoma Cells:, Cancer Research, vol. 61, No. 2, Jan. 15, 2001, pp. 497-503.
Nanjoo et al., “A New Ligand For the Peroxisome Proliferator-Activated Inhibits Rat Mammary Carcinogenesis”, Cancer Research, vol. 59, No. 22, Nov. 15, 1999, pp. 5671-5673.

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