Compositions useful for the treatment of microbial infections

Details Compositions useful for the treatment of microbial infections Compositions useful for the treatment of microbial infections

2011-01-25

2011-01-25

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S027000, C540S017000

Reexamination Certificate

active

07875598

ABSTRACT:
The present invention is based on the discovery that certain chemical compounds isolated from Chinese medicinal herbs are useful as anti-microbial agents, e.g., anti-bacterial agents, anti-fungal agents, and the like. In particular, the present invention provides compositions useful for treating microbial infections such as, for example, oral microbial infections, including periodontal disease and dental caries.

REFERENCES:
patent: 4150116 (1979-04-01), Taubman et al.
patent: 4250262 (1981-02-01), Taubman et al.
patent: 4324782 (1982-04-01), Beck
patent: 4442085 (1984-04-01), Colman et al.
patent: 4448768 (1984-05-01), Colman et al.
patent: 4521513 (1985-06-01), Russell
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4693888 (1987-09-01), Miyahara et al.
patent: 4725428 (1988-02-01), Miyahara et al.
patent: 5057313 (1991-10-01), Shih et al.
patent: 5281524 (1994-01-01), Horikoshi et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5352446 (1994-10-01), Lehner
patent: 5352450 (1994-10-01), Koga et al.
patent: 5439680 (1995-08-01), Horikoshi et al.
patent: 5518721 (1996-05-01), Lehner et al.
patent: 5612031 (1997-03-01), Lehner et al.
patent: 5645835 (1997-07-01), Fell, Jr. et al.
patent: 5646119 (1997-07-01), Oppenheim et al.
patent: 5672351 (1997-09-01), Chikindas et al.
patent: 5686075 (1997-11-01), Taubman et al.
patent: 5726293 (1998-03-01), Seed
patent: 5851527 (1998-12-01), Hansen
patent: 5874068 (1999-02-01), Engelman et al.
patent: 5875798 (1999-03-01), Petrus
patent: 5877293 (1999-03-01), Adair et al.
patent: 5891422 (1999-04-01), Pan et al.
patent: 5910573 (1999-06-01), Pluckthun et al.
patent: 5981726 (1999-11-01), Pastan et al.
patent: 6046037 (2000-04-01), Hiatt et al.
patent: 6183744 (2001-02-01), Goldenberg
patent: 6197299 (2001-03-01), Dohlsten et al.
patent: 6231857 (2001-05-01), Shi et al.
patent: 6254856 (2001-07-01), Tsuchiya
patent: 6309835 (2001-10-01), Iyer et al.
patent: 6346267 (2002-02-01), Fry et al.
patent: 6492328 (2002-12-01), Lehrer et al.
patent: 6559176 (2003-05-01), Bassler et al.
patent: 6673900 (2004-01-01), Rowe
patent: 2002/0068066 (2002-06-01), Shi et al.
patent: 2002/0102316 (2002-08-01), Weissman
patent: 2003/0143234 (2003-07-01), Shi et al.
patent: 2003/0171421 (2003-09-01), Davies et al.
patent: 2003/0186916 (2003-10-01), Yu et al.
patent: 2003/0211185 (2003-11-01), Alexis
patent: 2003/0228379 (2003-12-01), Shi et al.
patent: 2003/0229000 (2003-12-01), Merritt et al.
patent: 2004/0023254 (2004-02-01), Fuhrmann et al.
patent: 2004/0052814 (2004-03-01), Shi et al.
patent: 2004/0137482 (2004-07-01), Eckert et al.
patent: 2004/0147595 (2004-07-01), Kjelleberg et al.
patent: 2004/0234662 (2004-11-01), Ben-Yehoshua
patent: 2005/0255128 (2005-11-01), Merritt et al.
patent: 2005/0288229 (2005-12-01), Sindrey et al.
patent: 2006/0135498 (2006-06-01), Shi et al.
patent: 1415301 (2003-05-01), None
patent: 0 140 498 (1985-05-01), None
patent: 0 334 467 (1989-09-01), None
patent: 2 143 829 (1985-02-01), None
patent: 77021571 (1977-06-01), None
patent: 2-177899 (1990-07-01), None
patent: 5-227916 (1993-09-01), None
patent: 6-122633 (1994-05-01), None
patent: 2000-198724 (2000-07-01), None
patent: WO 92/22653 (1992-12-01), None
patent: WO 94/09817 (1994-05-01), None
patent: WO 99/58141 (1999-11-01), None
patent: WO 00/11037 (2000-03-01), None
patent: WO 01/85664 (2001-11-01), None
patent: WO 01/85664 (2001-11-01), None
patent: WO 02/15931 (2002-02-01), None
patent: WO 02/22686 (2002-03-01), None
patent: WO 02/22686 (2002-03-01), None
patent: WO 02/102975 (2002-12-01), None
patent: WO 02/102975 (2002-12-01), None
patent: WO 2004/028519 (2004-04-01), None
Deng et al. “Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7”, Carbohydrate Research, 1999, vol. 317, pp. 53-62.
Hufford et al. “Antifungal activity ofTrillium grandiflorumconstituents” Journal of Natural Products, Jan.-Feb. 1988, vol. 51, No. 1, pp. 94-98.
Haraguchi et al. “Mode of the Antifungal Action of Chrysodin inCandida albicans” Agric. Biol. Chem., 1990, vol. 54, No. 9, pp. 2417-2422.
Nakamoto et al. “In vitro study on the effects of trial dinture cleansers with berberine hydrochloride” J Prosthet Dent, 1995, vol. 73, pp. 530-533.
Tan et al. “Acyl secoiridoids and antifungal constituents fromGentiana macrophylla” Phytochemistry, 1996, vol. 42., No. 5, pp. 1305-1313.
International Search Report.
Arakawa, T. et al., “Plants are not just Passive Creatures!”Nature Medicine, May 1998, vol. 4, No. 5, pp. 550-551.
Barbeau, J. et al., “Biofilms, Infectious Agents, and Dental Unit Waterlines: A Review,”Can. J. Microbiol., 1998, vol. 44, pp. 1019-1028.
Bassler, B.L., “How Bacteria Talk to Each Other: Regulation of Gene Expression by Quorum Sensing,”Current Opinion in Microbiology, 1999, vol. 2, pp. 582-587.
Bhagwat, S.P. et al., “Effects of Mutating Putatuve Two-Component Systems on Biofilm Formation byStreptococcus mutansUA159,”FEMS Microbiology Letters, 2001, vol. 205, pp. 225-230.
Blondelle, S.E. et al., “Combinatorial Libraries: A Tool to Design Antimicrobial and Antifungal Peptide Analogues Having Lytic Specificities for Structure-Activity Relationship Studies,”Biopolymers, 2000, vol. 55, pp. 74-87.
Bowie, J.U. er al., “Deciphering the Message in Protein sequences: tolerance to Amino Acid Substitutions,”Science, Mar. 6, 1990, vol. 247, pp. 1306-1310.
Brogden, K.A. et al., “Antimicrobial Peptides in Animals and Their Role in Host Defences,”International Journal of Antimicrobial Agents, 2003, vol. 22, pp. 465-478.
Brogden, K.A., “Antimicrobial Peptides: Pore Formers or Metabolic Inhibitors in Bacteria?”Nature Reviews Microbiology, Mar. 2005, vol. 3, pp. 238-250.
Chen, P. et al., “The Specific Genes for Lantobiotic Mutacin II Biosynthesis inStreptococcus mutans, T8 are Clustered and Can be Transferred en Bloc,”Applied and Environmental Microbiology, Mar. 1999, vol. 65, No. 3, pp. 1356-1360.
Chen, X. et al., “Structural Identification of the Bacterial Quorum-Sensing Signal Containign Boron,”Nature, Jan. 31, 2002, vol. 415, pp. 545-549.
Chung, W.O. et al., “Signaling Systems inPorphyromonas gingivalisBased on a LuxS Protein,”Journal of Bacteriology, Jul. 2001, vol. 183, No. 13, pp. 3903-3909.
Davey, M.E. et al., “Microbial Biofilms: Form Ecology to Molecular Genetics,”Microbiology and Molecular Biology Reviews, Dec. 2000, vol. 64, No. 4, pp. 847-867.
Davies, D.G. et al., “The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm,”Science, Apr. 10, 1998, vol. 280, pp. 295-298.
Day, W.A., Jr. et al., “Shigella flexneriLuxS Quorum-Sensing System ModulatesvirBExpression but is Not Essential for Virulence,”Infection and Immuity, Jan. 2001, vol. 69, No. 1, pp. 15-23.
DeSlouches, B. et al., “De Novo Generation of Cationic Antimicrobial Peptides: Influence of Length and Tryptophan Substitution on Antimicrobial Activity,”Antimicrobial Agents and Chemotherapy, Jan. 2005, vol. 49, No. 1, pp. 316-322.
Diamond, G., “Nature's Antibiotics: The Potential of Antimicrobial Peptides as New Drugs,”Biologist, 2001, vol. 48, No. 5, pp. 209-212.
Dunny, G.M. et al., “Cell-Cell Communication in Gram-Positive Bacteria,”Annu. Rev. Microbiol., 1997, vol. 51, pp. 527-564.
European Examination Report mailed on Feb. 21, 2007, for EP Application No. EP 02752402.4 filed on Jul. 17, 2002, 6 pages.
European Examination Report mailed on May 16, 2008, for EP Application No. 02752402.4 filed on Jul. 17, 2002, 7 pages.
European Search Report mailed on Sep. 9, 2005, for EP Application No. EP 02752404.4, 4 pages.
Everhart, D.L. et al., “Dental Caries Vaccines: Some Problems Solved?”Microbiological Science, 1985, vol. 2, No. 10, pp. 312-313.
Fong, K.P. et al., “Intra- and Interspecies Regulation of Gene Expression byActinobacillus actinomycetemcomitansLuxS,&

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