Compositions useful as inhibitors of protein kinases

Details Compositions useful as inhibitors of protein kinases Compositions useful as inhibitors of protein kinases

2004-02-04

2009-10-13

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S224000, C544S235000, C544S236000

Reexamination Certificate

active

07601718

ABSTRACT:
The present invention provides a compound of formula I:or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

REFERENCES:
patent: 4004009 (1977-01-01), Anderson
patent: 6342601 (2002-01-01), Bantick et al.
patent: 2003-82251 (2003-03-01), None
patent: WO 02/22601 (2002-03-01), None
patent: WO 03/080616 (2003-10-01), None
patent: WO 2004/072029 (2004-08-01), None
Ghozlan et al., “Synthesis of polyfunctionally substited pyridazines”, Liebigs Ann. Chem, 1990, 293-296.
Patel et al., “Synthesis and Biological Activity of Substituted 1,4,5,6-tetrahydropyridazin-4-ones, 5,6-dihydro-3-hydroxy-1H-pyrazolo [4,3-c]pyridazines and 2,8-dihydro-1H-pyrano[2,3-d]pyridazines”, Indian Journal of Chemistry, vol. 28B, pp. 733-744, Sep. 1989.
Ghozlan et al., “Synthesis of Polyfunctionally Substituted Pyridazines”, Liebigs Ann. Chem., pp. 293-296, 1990.
Ghozlan et al., “Reactions with 3-oxo-2-phenylhydrazonobutyronitrile: New Routes for the Synthesis of Pyridazines”, Gazzetta Chimica Italiana, vol. 119, pp. 95-97, 1989.
Witherington et al., “5-Aryl-pyrazolo[3,4-b]pyridazines: Potent Inhibitors of Glycogen Synthase Kinase-3 (GSK-3)”, Bioorganic & Medical Chemistry Letters, vol. 13, pp. 1581-1584, 2003.

Affiliated with

Also associated with

Rating

Compositions useful as inhibitors of protein kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions useful as inhibitors of protein kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions useful as inhibitors of protein kinases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4081549