Compositions useful as inhibitors of protein kinases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S275000, C544S122000, C544S296000, C544S331000

Reexamination Certificate

active

10738965

ABSTRACT:
The present invention provides a compound of formula (I):or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3, JAK-3, FLT-3, PIM-1, SYK, or PDK-1 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

REFERENCES:
patent: 6093716 (2000-07-01), Davis et al.
patent: 6825190 (2004-11-01), Moon et al.
patent: WO 97/19065 (1997-05-01), None
patent: WO 97/19065 (1997-05-01), None
patent: WO 00/78731 (2000-12-01), None
patent: WO 01/00207 (2001-01-01), None
patent: WO 01/00214 (2001-01-01), None
patent: WO 01/00214 (2001-01-01), None
patent: WO 01/12621 (2001-02-01), None
patent: WO 01/29009 (2001-04-01), None
patent: WO 01/72745 (2001-10-01), None
patent: WO 01/72745 (2001-10-01), None
patent: WO 02/102800 (2002-12-01), None
Damasio, Alzheimer's Disease and Related Dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.
Layzer, Degenerative diseases of the Nervous System, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-2057, 1996.
Casanova et al., PubMed Abstract (Rev Neurol 28(9):909-15) May 1999.
Douglas, Jr. Introduction to Viral Diseases, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1739-1747, 1996.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Hardt et al., Glycogen Synthase Kinase-3beta A Novel Regulator of Cardiac Hypertrophy and Development, Circulation Research, 90:1055-1063, 2002.
Traxler, Protein Tyrosine Kinase inhibitors in cancer treatment, Exp. Opin. Ther. Patents, 7(6):571-588, 1997.
Changelian et al., “Prevention of organ allograft rejection by a specific janus kinase 3 inhibitor,” Science, 302:875-878, (2003).
Malaviya et al., “Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′,5′—dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97),” The Journal of Pharmacology and Experimental Therapeutics, 295(3):912-926, (2000).
Trieu et al., “A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis,” Biochemical and Biophysical Research Communications, 267:22-25, (2000).
Zimmerman et al., “Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives,” Bioorg. Med. Chem. Lett., 7(2):187-192, (1997)
Duhe et al., “Negative regulation of janus kinases”, Cell Biochemistry and Biophysics, 34(1):17-59, (2001).
Rane et al., “Janus kinases: components of multiple signaling pathways” Oncogene 19(49):5662-79, (2000).
Kim et al., “GSK3, a master switch regulating cell-fate specification and tumorigenesis”, Current Ioinion in Genetics & Development, 10(5):508-514, (2000).

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