Compositions useful as inhibitors of JAK and other protein...

Details Compositions useful as inhibitors of JAK and other protein... Compositions useful as inhibitors of JAK and other protein...

2007-08-21

2007-08-21

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S090000, C544S105000, C544S350000, C544S354000

Reexamination Certificate

active

10700936

ABSTRACT:
The present invention provides a compound of formula I:or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

REFERENCES:
patent: WO97/19065 (1997-05-01), None
patent: WO 02/083668 (2002-10-01), None
patent: WO 02/102800 (2002-12-01), None
LS Steelman et al., “JAK/STAT, Raf/MEK/ERK, P13K/Akt and BCR-ABL In Cell Cycle Progression And Leukemogenesis”, Leukemia 18: 189-218 (2004).
Francois-Xavier Mahon, “JAK The Trigger”, Oncogene 24: 7125-7126 (2005).
Stefan Faderl et al., “WP-1034, A Novel JAK-STAT Inhibitor, with Proapoptotic and Antileukemic Activity in Acute Myeloid Leukemia (AML)”, Anticancer Research 25: 1841-1850 (2005).
Elisa A. Sudbeck et al., “Structure-based Design of Specific Inhibitors Of Janus Kinase 3 As Apoptosis-Inducing Antileukemic Agents”, Clinical Cancer Research, 5; 1569-1582 (1999).

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