Compositions useful as a cannabinoid receptor probe

Details Compositions useful as a cannabinoid receptor probe Compositions useful as a cannabinoid receptor probe

1995-08-08

1999-02-16

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549390, A61K 3135, C07D31180

Patent

active

058721487

ABSTRACT:
A composition of matter, comprising a cannabinol compound having the structure ##STR1## wherein, Q is --C(R.sup.1)(Y.sup.1)--(CH.sub.2).sub.n --Z.sup.1 ; R.sup.1 is --H or --CH.sub.3 ;

REFERENCES:
patent: 3897306 (1975-07-01), Vidic et al.
Reggio, P.H. et al., "Characterization of a Region of Steric Interference at the Cannabinoid Receptor Using the Active Analog Approach", J. Med. Chem. United States, 36(12):1761-1771, (Jun. 11, 1993).
Gold, L.H. et al., "A Comparison of the Discriminative Stimulus Properties of .DELTA..sup.9 -Tetrahydrocannabinol and CP 55,940 in Rats and Rhesus Monkeys", J. Pharmacol. Exp. Ther., 262(2):479-486, (Aug. 1992).
Charalambous, A. et al., "Pharmacological Evaluation of Halogenated .DELTA..sup.8 -THC Analogs", Pharmacol. Biochem. Behav., 40(3):509-512 (Nov. 1991).
Martin, B.R. et al., "Behavioral, Biochemical, and Molecular Modeling Evaluations of Cannabinoid Analogs", Pharmacol. Biochem. Behav., 40(3):471-478 (Nov. 1991).
Compton, D.R. et al., "Synthesis and Pharmacological Evaluation of Ether and Related Analogues of .DELTA..sup.8 -, .DELTA..sup.9 -, and .DELTA..sup.9,11 -Tetrahydrocannabinol", J. Med. Chem., 34(11):3310-3316 (Nov. 1991).
Burstein, S.H. et al., "Detection of Cannabinoid Receptors by Photoaffinity Labelling", Biochem. Biophys. Res. Commun., 176(1):492-497 (Apr. 15, 1991).
Howlett, A.C. et al., "Stereochemical Effects of 11-OH-.DELTA..sup.8 -Tetrahydrocannabinol-Dimethylheptyl to Inhibit Adenylate Cyclase and Bind to the Cannabinoid Receptor", Neuropharmacology, 29(2):161-165 (Feb. 1990).
Nye, J.S. et al., "High-Affinity Cannabinoid Binding Sites in Brain -Tetrahydrocannabinol", J. Pharmacol. Exp. Ther., 234(3):784-791 (1985).
Charalambous, A., et al., "5'-Azido-.DELTA..sup.8 -THC: A Novel Photoaffinity Label for the Cannabinoid Receptor", J. Med. Chem., 35:3076-3079, (1992).
The Merck Index, Eleventh Edition, Entry #9142, (1989).

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