Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-04-18
2006-04-18
Winkler, Ulrike (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C530S350000, C536S023100, C536S024310, C536S024330
Reexamination Certificate
active
07030235
ABSTRACT:
The invention provides isolated nucleic acids molecules, designated COCH5B2 nucleic acid molecules, which encode polypeptides involved in inner ear biology. The invention also provides antisense nucleic acid molecules, expression vectors containing COCH5b2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a COCH5b2 gene has been introduced or disrupted. The invention still further provides isolated COCH5B2 polypeptides, fusion polypeptides, antigenic peptides, and anti-COCH5B2 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
REFERENCES:
patent: WO 99/14328 (1999-03-01), None
Robertson et al. Mapping and characterization of a novel cochlear gene in human and in mouse: a positional canidate gene for deafness disorder, DFNA9. Genomics. vol. 46 (Dec. 1997) pp. 345-354.
GenBank/EMBL Database, accession # AF006740, # AF006741 (Jun. 4, 1997).
Heller et al. Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Proceedings of the National Academey of Sciences. vol. 95 (1998) pp. 11400-11405.
GenBank/EMBL Database, accession # AF012252 (Jul. 2, 1997).
VanCoillie et al. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2 Genomics. vol. 40 (Mar. 1997) pp. 323-331.
GenBank/EMBL Database, accession # Z78142 (Aug. 6, 1996).
GenBank/EMBL Database, accession # U09203 (Apr. 25, 1994).
Scott et al. The pendered syndrome gene encodes a chloride-iodide transport protein. Nature Genetics (1999) vol. 21, pp. 440-443.
Riffkin et al. A single amino-acid change between the antigenically different extracellular serine proteases V2 and B2 fromDichelobacter nodosus. Gene (1995) vol. 167, pp. 279-283.
Harris et al. Polycystic kidney disease. 1: Identification and analysis of the primary defect. Journal of the American Society of Nephrology (1995) vol. 6, pp. 1125-1133.
Ahn et al. The structural and functional diversity of distophin. Nature Genetics (1993) vol. 3, pp. 283-291.
Cawthon et al. cDNA sequnece and Genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene. Genomics (1991) vol. 9, pp. 446-460.
Duyk et al. (1992)Nature Genet., 2:5-8.
Petit et al. (1996)Nature Genet., 14:385-391.
van Camp et al. (1997)Am. J. Human Genet., 60:758-764.
deKok et al. (1995)Science, 267:685-688.
Liu et al. (1997)Nature Genet., 16:188-190.
Weil et al. (1997)Nature Genet., 16:191-193.
Kelsell et al. (1997)Nature, 387:80-83.
Robertson et al. (1994)Genomics, 23:42-50.
Colombatti et al. (1993)Matrix, 77:2305-2315.
Colombatti et al. (1993)Matrix, 13:297-306.
Bonaldo et al. (1990)Biochemistry, 29:1245-1254.
Gerecke et al. (1997)Genomics, 41:236-242.
Jenkins et al. (1990)J. Biol. Chem., 265:19624-19631.
Mancuso et al. (1991)Biochemistry, 30:253-269.
Bonaldo et al. (1989)J. Biol. Chem., 264:5575-5580.
Koller et al. (1989)EMBO J., 8:1073-1077.
Parente et al. (1991)PNAS USA, 88:6931-6935.
Christiano et al. (1994)J. Biol. Chem., 269:20256-20262.
Wälchi et al. (1993)Eur. J. Biochem., 212:483-490.
Agraves et al. (1987)PNAS USA, 84:464-468.
Haudenschild et al. (1995)J. Biol., 270:23150-23154.
Roth et al. (1986)Biochemistry, 25:8357-8361.
Kalafatis et al. (1987)Blood, 70:1577-1583.
Pareti et al. (1987)J. Biol. Chem., 262:13835-13847.
Manolis et al. (1996)Hum. Mol. Genet., 5:1047-1050.
Khetarpal et al. (1991)Arch. Otolaryngol. Head&Neck Surg., 117:1032-1042.
Khetarpal et al. (1993)Arch. Otolaryngol. Head&Neck Surg., 119:106-108.
Fishman et al. (1983)Arch. Ophthalmal., 101:1367-1374.
Collins & Fuller (1968)Science, 162:1137-1139.
Halpin et al. (1996)Am. J. Audiol., 5:105-111.
Muta et al. (1991)J. Biol. Chem., 266:6554.
Iwanaga et al. (1992)Thrombosis Res., 68:1.
Nakamura et al. (1998)Eur. J. Biochem., 176:89.
Steel et al. (1994)Trends in Genet., 10:428-434.
Morton Cynthia C.
Robertson Nahid
The Brigham & Women's Hospital, Inc.
Winkler Ulrike
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