Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-01-08
2008-01-08
Rawlings, Stephen L. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023500, C536S024330, C536S024310, C436S064000
Reexamination Certificate
active
10656895
ABSTRACT:
A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed ars are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.
REFERENCES:
patent: 4022878 (1977-05-01), Gross
patent: 4329281 (1982-05-01), Christenson et al.
patent: 4526716 (1985-07-01), Stevens
patent: 4584268 (1986-04-01), Ceriani et al.
patent: 4601896 (1986-07-01), Nugent
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4729893 (1988-03-01), Letcher et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4818709 (1989-04-01), Primus et al.
patent: 4849227 (1989-07-01), Cho
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4945050 (1990-07-01), Sanford et al.
patent: 4963263 (1990-10-01), Kauvar
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5017487 (1991-05-01), Stunnenberg et al.
patent: 5037645 (1991-08-01), Strahilevitz
patent: 5075216 (1991-12-01), Innis et al.
patent: 5112606 (1992-05-01), Shiosaka et al.
patent: 5133866 (1992-07-01), Kauvar
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5160723 (1992-11-01), Welt et al.
patent: 5217869 (1993-06-01), Kauvar
patent: 5221736 (1993-06-01), Coolidge et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5237051 (1993-08-01), Garbers et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5324483 (1994-06-01), Cody et al.
patent: 5330892 (1994-07-01), Vogelstein et al.
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5340474 (1994-08-01), Kauvar
patent: 5350741 (1994-09-01), Takada
patent: 5352775 (1994-10-01), Albertsen et al.
patent: 5366862 (1994-11-01), Venton et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5395750 (1995-03-01), Dillon et al.
patent: 5399347 (1995-03-01), Trentham et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5420328 (1995-05-01), Campbell
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5430138 (1995-07-01), Urdea et al.
patent: 5437977 (1995-08-01), Segev
patent: 5518888 (1996-05-01), Waldman
patent: 5597909 (1997-01-01), Urdea et al.
patent: 5601990 (1997-02-01), Waldman
patent: 5731159 (1998-03-01), Waldman
patent: 5843761 (1998-12-01), Barnett et al.
patent: 5879656 (1999-03-01), Waldman et al.
patent: 5928873 (1999-07-01), Waldman
patent: 5962220 (1999-10-01), Waldman
patent: 6120995 (2000-09-01), Waldman et al.
patent: 6582908 (2003-06-01), Fodor et al.
patent: 6602659 (2003-08-01), Waldman et al.
patent: 85/02611 (1985-06-01), None
patent: WO90/11092 (1990-10-01), None
patent: WO95/11694 (1995-05-01), None
patent: WO97/42220 (1997-11-01), None
patent: WO97/42506 (1997-11-01), None
Adams, R.D., “Anxiety, Depression, Asthenia, and Personality Disorders” inHarrison's Principles of Internal Medicine, McGraw-Hill Book Co., N.Y., 1983, p. 68.
Alexander et al., “Oncogene alterations in rat colon tumors induced by N-methyl-N-nitrosourea”,Am. J. Med. Sci., 1992, 303(1), 16-24.
Beck-Sickinger et al., “Neuropeptide Y: identification of the binding site”,Int. J. Peptide Protein Res., 1990, 36, 522-530.
Berd et al., “Induction of Cell-mediated Immunity to Autologous Melanoma Cells and Regression of Metastases after Treatment with a Melanoma Cell Vaccine Preceded by Cyclophosphamide”,Cancer Res., 1986, 46, 2572-2577.
Berd et al., “Immunization with Haptenized, Autologous Tumor Cells Induces Inflammation of Human Melanoma Metastases”,Cancer Res., 1991, 51, 2731-2734.
Blond-Elguindi et al., “Affinity Panning of a Library of Peptides Displayed on Bacteriophages Reveals the Binding Specificity of BiP”,Cell, 1993, 75, 717-728.
Bold et al., “Expermental gene therapy of human colon cancer”,Surgery, 1994, 116(2), 189-196.
Ciardiello et al., “Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides”,Oncogene, 1994, 9(1), 291-298.
Collins et al., “c-mycantisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells”,J. Clin. Invest., 1992, 89(5), 1523-1527.
Cooney et al., “Site-Specific Oligonucleotide Binding Represses Transcription of the Humanc-mycGene in Vitro”,Science, 1988, 241, 456-459.
Coperhave et al., “The Digestive System”,Bailey's Textbook of Histology, 16th Edition, Williams and Wilkens, Baltimore, MD, 1975, p. 404.
Cull et al., “Screening for receptor ligands using large libraries of peptides linked to the C terminus of thelacrepressor”,Proc. Natl. Acad. Sci. USA, 1992, 89, 1865-1869.
Francis et al., Peptide Vaccines Based on Enhanced Immunogenicity of Peptide Epitopes Presented with T-Cell Determinants or Hepatitis B Core Protein,Methods in Enzymol., 1989, 178, 659-676.
Gallop et al., “Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries”,J. Med. Chem., 1994, 37(9), 1233-1251.
Gordon et al., “Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions”,J. Med.Chem., 1994, 37(10), 1385-1401.
Hammer et al., “Promiscuous and Allele-Specific Anchors in HLA-DR-Binding Peptides”,Cell, 1993, 74, 197-203.
Haralambidis et al., “The Solid Phase Synthesis of Oligonucleotides Containing a 3′-Peptide Moiety”,Tetra. Letts., 1987, 28(43), 5199-5202.
Helen et al., “Specific regulation of gene expression by antisense, sense, and antigene nucleic acids”,Biochem. Biophys. Acta, 1990, 1049, 99-125.
Kniazev et al., “Comprehensive Characteristics of Alterations of HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, and C-MYC Oncogenes, and of p53 and RBI Antioncogenes, and also of Deletions of Loci of Chromosome 17 in Colorectal Carcinomas”,Mol. Biol., 1992, 26(5), 1-15.
Kwok et al., “Calculation of radiation doses for nonuniformly distributed β and γ radionuclides in soft tissue”,Med. Phys., 1985, 12(4), 405-412.
Magerstadt, M.,Antibody Conjugates and Malignant Disease, CRC Press, Boca Raton, USA, 1991, 110-152.
Melani et al., “Inhibition of proliferation byc-mybantisense oligodeoxynucleotides in colon adenocarcinoma cell lines that expressc-myb”, Cancer Res., 1991, 51(11), 2897-2901.
Miller et al., “The Induction of Hapten-Specific T Cell Tolerance by Using Hapten-Modified Lymphoid Cells”,J. Immunol., 1976, 117(5:1), 1519-1526.
Nielsen et al., “Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand”,Gene, 1994, 149, 139-145.
Osteresh et al., “Libraries from libraries”: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity,Proc. Natl. Acad. Sci. USA, 1994, 91, 11138-11142.
Ohlmeyer et al., “Complex synthetic chemical libraries indexed with molecular tags”,Proc. Natl. Acad. Sci. USA, 1993, 90, 10922-10926.
Ramsey et al., “Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa”,Cell Growth&Different,, 1992, 3(10), 723-730.
Rodriguez-Alfageme et al., “Suppression of deregulated c
Barber Michael T.
Parkinson Scott J.
Pearlman Joshua M.
Schulz Stephanie
Waldman Scott A.
Pepper Hamilton LLP
Rawlings Stephen L.
Thomas Jefferson University
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