Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-11-14
2006-11-14
Rawlings, Stephen L. (Department: 1643)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C536S023100, C536S023500, C536S024300, C536S024310, C536S024330, C435S320100
Reexamination Certificate
active
07135333
ABSTRACT:
A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.
REFERENCES:
patent: 4022878 (1977-05-01), Gross
patent: 4329281 (1982-05-01), Christenson et al.
patent: 4526716 (1985-07-01), Stevens
patent: 4584268 (1986-04-01), Ceriani et al.
patent: 4601896 (1986-07-01), Nugent
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4729893 (1988-03-01), Letcher et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4849227 (1989-07-01), Cho
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4945050 (1990-07-01), Sanford et al.
patent: 4963263 (1990-10-01), Kauvar
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5017487 (1991-05-01), Stunnenberg et al.
patent: 5037645 (1991-08-01), Strahilevitz
patent: 5075216 (1991-12-01), Innis et al.
patent: 5112606 (1992-05-01), Shiosaka et al.
patent: 5133866 (1992-07-01), Kauvar
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5160723 (1992-11-01), Welt et al.
patent: 5217869 (1993-06-01), Kauvar
patent: 5221736 (1993-06-01), Coolidge et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5237051 (1993-08-01), Garbers et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5324483 (1994-06-01), Cody et al.
patent: 5330892 (1994-07-01), Vogelstein et al.
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5340474 (1994-08-01), Kauvar
patent: 5350741 (1994-09-01), Takada
patent: 5352775 (1994-10-01), Albertsen et al.
patent: 5366862 (1994-11-01), Venton et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5395750 (1995-03-01), Dillon et al.
patent: 5399347 (1995-03-01), Trentham et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5420328 (1995-05-01), Campbell
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5430138 (1995-07-01), Urdea et al.
patent: 5437977 (1995-08-01), Segev
patent: 5518888 (1996-05-01), Waldman
patent: 5597909 (1997-01-01), Urdea et al.
patent: 5601990 (1997-02-01), Waldman
patent: 5731159 (1998-03-01), Waldman
patent: 5928873 (1999-07-01), Waldman
patent: 5962220 (1999-10-01), Waldman
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: WO 95/11694 (1995-05-01), None
patent: WO 97/42220 (1997-11-01), None
patent: WO 97/42506 (1997-11-01), None
de Sauvage et al (Accession #M73489, 1991).
Singh et al (Accession # S57551, 1991.
Skolnick J, et al. Trends Biotech 2000; 18 (1): 34-39.
Database GENBANK, Accession No. AC010168, Sep. 19, 2000.
Database GENBANK, Accession No. AL359386, Jan. 20, 2001.
Boehringer Mannheim Biochemicals, 1994 Catalog (No. 1034 731/1006 924), p. 93.
Houdebine LM. J biotechnol. May 31, 1994; 34 (3): 269-87.
Verma IM, et al. Nature. Sep. 18, 1997; 389 (6648): 239-42.
Patterson AP, Memorandum (Jan. 14, 2003); pp. 3.
Pandha HS, et al. Cur Opin Invest Drugs. 2000; 1 (1): 122-34.
Amalfitano A, et al. Cur Gene Ther. 2002; 2: 111-33.
Waldman SA et al. (Cancer Epidemiol. Biomarkers Prev. Jun. 1998; 7 (6): 505-514).
Pearlman et al. (Dig. Dis. Sci. Feb. 2000; 45 (2): 298-305).
Adams, R.D., “Anxiety, Depression, Asthenia, and Personality Disorders” inHarrison's Principles of Internal Medicine, McGraw-Hill Book Co., N.Y., 1983, p. 68.
Alexander et al., “Oncogene alterations in rat colon tumors induced by N-methyl-N-nitrosourea”,Am. J. Med. Sci., 1992, 303(1), 16-24.
Beck-Sickinger et al., “Neuropeptide Y: identification of the binding site”,Int. J. Peptide Protein Res., 1990, 36, 522-530.
Berd et al., “Induction of Cell-mediated Immunity to Autologous Melanoma Cells and Regression of Metastases after Treatment with a Melanoma Cell Vaccine Preceded by Cyclophosphamide”,Cancer Res., 1986, 46, 2572-2577.
Berd et al., “Immunization with Haptenized, Autologous Tumor Cells Induces Inflammation of Human Melanoma Metastases”,Cancer Res., 1991, 51, 2731-2734.
Blond-Elguindi et al., “Affinity Panning of a Library of Peptides Displayed on Bacteriophages Reveals the Binding Specificity of BiP”,Cell, 1993, 75, 717-728.
Bold et al., “Experimental gene therapy of human colon cancer”,Surgery, 1994, 116(2), 189-196.
Ciardiello et al., “Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides”,Oncogene, 1994, 9(1), 291-298.
Collins et al., “c-mycantisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells”,J. Clin. Invest., 1992, 89(5), 1523-1527.
Cooney et al., “Site-Specific Oligonucleotide Binding Represses Transcriptionof the Humanc-mycGene in Vitro”,Science, 1988, 241, 456-459.
Coperhave et al., “The Digestive System”,Bailey's Textbook of Histology, 16th Edition, Williams and Wilkens, Baltimore, MD, 1975, p. 404.
Cull et al., “Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor”,Proc. Natl. Acad. Sci. USA, 1992, 89, 1865-1869.
Francis et al., Peptide Vaccines Based on Enhanced Immunogenicity of Peptide Epitopes Presented with T-Cell Determinants or Hepatitis B Core Protein,Methods in Enzymol., 1989, 178, 659-676.
Gallop et al., “Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries”,J. Med. Chem., 1994, 97(9), 1233-1251.
Gordon et al., “Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions”,J. Med.Chem., 1994, 37(10), 1385-1401.
Hammer et al., “Promiscuous and Allele-Specific Anchors in HLA-DR-Binding Peptides”,Cell, 1993, 74, 197-203.
Haralambidis et al., “The Solid Phase Synthesis of Oligonucleotides Containing a 3′- Peptide Moiety”,Tetra. Letts., 1987, 28(43), 5199-5202.
Helen et al., “Specific regulation of gene expression by antisense, sense, and antigene nucleic acids”,Biochem. Biophys, Acta, 1990, 1049, 99-125.
Kniazev et al., “Comprehensive Characteristics of Alterations of HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, and C-MYC Oncogenes, and of p53 and RBI Antioncogenes, and also of Deletions of Loci of Chromosome 17 in Colorectal Carcinomas”,Mol. Biol., 1992, 26(5), 1-15.
Kwok et al., “Calculation of radiation doses for nonuniformly distributed β and γ radionuclides in soft tissue”,Med. Phys., 1985, 12(4), 405-412.
MacLean et al., “Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant”,Cancer Immunol. Immunother., 1993, 36, 215-222.
Magerstadt, M.,Antibody Conjugates and Malignant Disease, CRC Press, Boca Raton, USA, 1991, 110-152.
Melani et al., “Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb”,Cancer Res., 1991, 51(11), 2897-2901.
Miller et al., “The Induction of Hapten-Specific T Cell Tolerance by Using Hapten-Modified Lymphoid Cells”,J. Immunol., 1976, 117(5:1), 1519-1526.
Nielsen et al., “Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand”,Gene,
Barber Michael T.
Parkinson Scott J.
Pearlman Joshua M.
Schulz Stephanie
Waldman Scott A.
Cozen O'Connor P.C.
Rawlings Stephen L.
Thomas Jefferson University
LandOfFree
Compositions that specifically bind to colorectal cancer... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions that specifically bind to colorectal cancer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions that specifically bind to colorectal cancer... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3700419