Compositions that inhibit wound contraction and methods of using

Details Compositions that inhibit wound contraction and methods of using Compositions that inhibit wound contraction and methods of using

1995-06-06

1998-12-22

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

058519947

ABSTRACT:
The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a peptide or a polypeptide. The invention provides, for example, a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide having more than three consecutive basic amino acids. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide containing the sequence arginine-glycine-aspartic acid and a basic amino acid sequence or a pharmaceutical composition comprising a peptide containing therein a sequence of six consecutive amino acid residues of which at least about four of the six amino acid residues are basic amino acid residues. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising decorin.

REFERENCES:
patent: 5510328 (1996-04-01), Polarek et al.

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