Compositions suitable for human topical application including a

Details Compositions suitable for human topical application including a Compositions suitable for human topical application including a

1986-09-26

1990-05-29

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 854, 424 857, 424 851, A61K 3766, A61K 4505, A61K 3702

Patent

active

049294423

ABSTRACT:
Compositions containing a tissue plasminogen activator (t-PA), epidermal growth factor (EGF), transforming growth factor-alpha (TGF.alpha.), transforming growth factor-beta (TGF-.beta.), human endothelial cell growth factor (ECGF), granulocyte macrophage colony stimulating factor (GM-CSF) and a fibronectin or large external transformation sensitive protein (LETS) including cell surface protein (CSP), cell adhesion protein (CAP), cell insoluble globulin (CIG) and/or opsonic-alpha 2 surface binding glycoprotein in a suitable physiologically acceptable carrier are useful for the treatment of humans when topically and/or subcutaneously applied. These compositions might also usefully contain or have employed in association therewith an adjuvant to aid in the transdermal transport or transfer of the compositions, particularly the active components therein, through or across the skin. Also, these compositions might also have contained therein or employed in association therewith an antiviral agent, such as an antiviral surfactant, for example, an antiviral nonionic surfactant, e.g. nonylphenoxypolyethoxy ethanol and/or human interferon, e.g. alpha-interferon. Additionally, these compositions might contain or have employed in association therewith an antitumor agent, such as tumor necrosis factor (TNF), target cell lysis factor (TCLF) and carcino-breaking factor (CBF). These compositions are useful in the treatment or healing of humans, e.g. in the treatment of viral and/or cancerous skin disorders or lesions and/or to expedite healing.

REFERENCES:
patent: 3917824 (1975-11-01), Camble et al.
patent: 3948875 (1976-04-01), Cohen et al.
patent: 4373519 (1983-02-01), Errede et al.
patent: 4507281 (1985-03-01), Asculai et al.
patent: 4609546 (1986-09-01), Hiratani
patent: 4621052 (1986-11-01), Sugimoto
patent: 4743679 (1988-05-01), Cohen et al.

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