Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2009-11-12
2011-10-04
Rao, Manjunath (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S193000, C435S252330, C435S488000
Reexamination Certificate
active
08030028
ABSTRACT:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
REFERENCES:
patent: 6927042 (2005-08-01), Schultz et al.
patent: 7045337 (2006-05-01), Schultz et al.
patent: 7083970 (2006-08-01), Schultz et al.
patent: 7129333 (2006-10-01), Schultz et al.
patent: 7183082 (2007-02-01), Schultz et al.
patent: 7199222 (2007-04-01), Shultz et al.
patent: 7217809 (2007-05-01), Schultz et al.
patent: 7238510 (2007-07-01), Schultz et al.
patent: 7262040 (2007-08-01), Schultz et al.
patent: 7354761 (2008-04-01), Schultz et al.
patent: 7368275 (2008-05-01), Schultz et al.
patent: 7378263 (2008-05-01), Schultz et al.
patent: 7399619 (2008-07-01), Xie et al.
patent: 7432092 (2008-10-01), Schultz et al.
patent: 7494796 (2009-02-01), Alfonta et al.
patent: 7524647 (2009-04-01), Schultz et al.
patent: 7527943 (2009-05-01), Anderson et al.
patent: 7560535 (2009-07-01), Schultz et al.
patent: 7575895 (2009-08-01), Anderson et al.
patent: 7608423 (2009-10-01), Chin et al.
patent: 7638297 (2009-12-01), Anderson et al.
patent: 7638300 (2009-12-01), Schultz et al.
patent: 7642085 (2010-01-01), Schultz et al.
patent: 2004/0265952 (2004-12-01), Deiters et al.
patent: 2005/0009049 (2005-01-01), Chin et al.
patent: 2005/0136513 (2005-06-01), Zhang et al.
patent: 2005/0208536 (2005-09-01), Schultz et al.
patent: 2005/0250183 (2005-11-01), Schultz et al.
patent: 2006/0063244 (2006-03-01), Schultz et al.
patent: 2006/0073507 (2006-04-01), Deiters et al.
patent: 2006/0110784 (2006-05-01), Deiters et al.
patent: 2006/0110796 (2006-05-01), Schultz et al.
patent: 2006/0134746 (2006-06-01), Deiters et al.
patent: 2006/0160175 (2006-07-01), Anderson et al.
patent: 2006/0246509 (2006-11-01), Deiters et al.
patent: 2007/0009990 (2007-01-01), Alfonta et al.
patent: 2007/0111193 (2007-05-01), Zhang et al.
patent: 2007/0154952 (2007-07-01), Chin et al.
patent: 2007/0172915 (2007-07-01), Schultz et al.
patent: 2007/0178448 (2007-08-01), Tsao et al.
patent: 2007/0238152 (2007-10-01), Wang et al.
patent: 2007/0281335 (2007-12-01), Ryu et al.
patent: 2008/0044886 (2008-02-01), Wang et al.
patent: 2008/0064059 (2008-03-01), Schultz et al.
patent: 2008/0113407 (2008-05-01), Liu et al.
patent: 2008/0166766 (2008-07-01), Liu et al.
patent: 2008/0166783 (2008-07-01), Schultz et al.
patent: 2008/0167243 (2008-07-01), Schultz et al.
patent: 2008/0171317 (2008-07-01), Deiters et al.
patent: 2008/0176277 (2008-07-01), Chin et al.
patent: 2008/0213828 (2008-09-01), Schultz et al.
patent: 2008/0220472 (2008-09-01), Deiters et al.
patent: 2008/0227152 (2008-09-01), Schultz et al.
patent: 2008/0227153 (2008-09-01), Schultz et al.
patent: 2008/0227195 (2008-09-01), Chin et al.
patent: 2008/0233611 (2008-09-01), Schultz et al.
patent: 2008/0241903 (2008-10-01), Schultz et al.
patent: 2008/0261311 (2008-10-01), Schultz et al.
patent: 2009/0053791 (2009-02-01), Schultz et al.
patent: 2009/0068717 (2009-03-01), Schultz et al.
patent: 2009/0081690 (2009-03-01), Deiters et al.
patent: 2009/0137424 (2009-05-01), Tsao et al.
patent: 2009/0148887 (2009-06-01), Brustad et al.
patent: 2009/0163368 (2009-06-01), Liu et al.
patent: 2009/0181429 (2009-07-01), Ryu et al.
patent: 2009/0181858 (2009-07-01), Deiters et al.
patent: 2009/0197339 (2009-08-01), Young et al.
patent: 2009/0208994 (2009-08-01), Seyedsayamdost et al.
patent: 2009/0209000 (2009-08-01), Wang et al.
patent: 2009/0215117 (2009-08-01), Schultz et al.
patent: 2009/0227002 (2009-09-01), Schultz et al.
patent: 2009/0263376 (2009-10-01), Grunewald et al.
patent: 2009/0286279 (2009-11-01), Liu et al.
patent: 2009/0298119 (2009-12-01), Wang et al.
patent: 2009/0298124 (2009-12-01), Alfonta et al.
patent: 2010/0009425 (2010-01-01), Schultz et al.
patent: 2010/0021963 (2010-01-01), Liu et al.
patent: WO 02/085923 (2002-10-01), None
patent: WO 2009/064416 (2009-05-01), None
patent: WO 2009/151491 (2009-12-01), None
Anderson and Schultz (2003) “Adaptation of an Orthogonal Archaeal Leucyl-tRNA and Synthetase Pair for Four-base, Amber, and Opal Suppression.”Biochemistry, 42: 9598-9608.
Anderson et al. (2004) “An expanding genetic code with a functional quadruplet codon.”Proceedings of the National Academy of Sciences, USA, 101(20): 7566-7571.
Anderson et al. (2002) “Exploring the limits of codon and anticodon size.”Chemistry&Biology, 9: 237-244.
Bossi and Roth (1981) “Four-base codons ACCA, ACCU and ACCC are recognized by frameshift suppressor sufJ.”Cell, 25(2): 489-496.
Chen et al. (1994) “Properties of the lysyl-tRNA synthetase gene and product from the extreme thermophileThermus thermophilus.” Journal of Bacteriology, 176(9): 2699-2705.
Chin and Schultz (2002) “In Vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis.”ChemBioChem, 3(11): 1135-1137.
Chin et al. (2003) “An expanded eukaryotic genetic code.”Science. 301: 964-967.
Chin et al. (2002) “Addition of a photocrosslinking amino acid to the genetic code ofEscherichia coli.” Proceedings of the National Academy of Sciences, USA, 99(17): 11020-11024.
Curran and Yarus (1987) “Reading frame selection and transfer RNA anticodon loop stacking.”Science, 238: 1545-1550.
Furter (1998) “Expansionof the genetic code: Site-directed p-fluoro-phenylalanine incorporation inEscherichia coli.” Protein Science, 7(2): 419-426.
Hohsaka and Sisido (2002) “Incorporation of non-natural amino acids into proteins.”Current Opinion in Chemical Biology, 6: 809-815.
Hohsaka et al., (1999) “Incorporation of two nonnatural amino acids into proteins through extension of the genetic code.”Nucleic Acids Symposium Series, 42: 79-80.
Hohsaka et al. (2001) “Five-base codons for incorporation of nonnatural amino acids into proteins.”Nucleic Acids Research, 29(17): 3646-3651.
Hou et al., (1992) “Novel transfer RNAs that are active inEscherichia coli.” Biochemistry, 31: 4157-4160.
Ibba et al. (1999) “Substrate recognition by class I lysyl-tRNA synthetases: a molecular basis for gene displacement.”Proceedings of the National Academy of Sciences, USA, 96(2): 418-423.
Kobayayashi et al. (2003) “Structural basis for orthogonal tRNA specific of tyrosyl-tRNA synthetases for genetic code expansion.”Nature Structural Biology, 10(6): 425-432.
Kwok and Wong (1980) “Evolutionary relationship betweenHalobacterium cutirubrumand eukaryotes determined by use of aminoacyl-tRNA synthetases as phylogenetic probes.”Canadian Journal of Biochemistry, 58: 213-218.
Magliery et al. (2001) “Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of “shifty” four-base codons with a library approach inEscherichia coli.” Journal of Molecular Biology, 307: 755-769.
Mehl et al. (2003) “Generation of a bacterium with a 21 amino acid genetic code.”Journal of the American Chemistry Society, 125: 935-939.
O'Connor (2002) “Insertions in the anticodon loop of tRNA(1)(Gln)(sufG) and tRNA(Lys) promote quadruplet decoding of CAAA.”Nucleic Acids Research, 30(9): 1985-1990.
Santoro et al. (2003) “An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins inEscherichia coli.” Nucleic Acids Research, 31(23): 6700-6709.
Santoro et al. (2002) “An efficient system for the evolution of aminoacyl-tRNA synthetase specificity.”Nature Biotechnology, 20:1044-1048.
Terada et al. (2002) “Functional convergence of two lysyl-tRNA synthetases with unrelated topologies.”Nature Structural Biology,
Anderson J. Christopher
Santoro Stephen
Schultz Peter G.
Wu Ning
Baker Gary
Gebreyesus Kagnew H
Quine Jonathan Alan
Quine Intellectual Property Law Group P.C.
Rao Manjunath
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