Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S193000, C435S252330, C435S488000

Reexamination Certificate

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07638297

ABSTRACT:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.

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Database Accession No. 057963; Abstract XP-002470658, Aug. 1, 1998.

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