Compositions of oral dissolvable medicaments

Details Compositions of oral dissolvable medicaments Compositions of oral dissolvable medicaments

1989-09-05

1994-02-22

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424441, 424435, 424434, 424484, A61K 968

Patent

active

052884970

ABSTRACT:
Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a carbohydrate, fat, protein, wax, or other dissolvable matrix composition. The dissolvable matrix may include permeation enhancers to increase the drug absorption by the mucosal tissues of the mouth. The matrix composition may also include pH buffering agents to modify the salival pH thereby increasing the absorption of the drug through the mucosal tissue.

REFERENCES:
patent: D93287 (1934-09-01), Reed
patent: D117455 (1989-11-01), Parr
patent: D117456 (1989-11-01), Parr
patent: 1971560 (1934-08-01), Guyon
patent: 2096611 (1937-10-01), Ellestad
patent: 2208120 (1940-07-01), Coleman
patent: 2246778 (1941-06-01), Cahoon
patent: 2295042 (1942-09-01), Lewellyn
patent: 2323656 (1943-07-01), Helfenstein
patent: 2388533 (1945-11-01), Edmondson et al.
patent: 2469589 (1949-05-01), Barricini
patent: 2488272 (1949-11-01), Davis
patent: 2499734 (1950-03-01), Edmondson et al.
patent: 2508560 (1950-05-01), Adams
patent: 2553446 (1951-05-01), Edmondson et al.
patent: 2857908 (1958-10-01), Cornfield
patent: 2897624 (1959-08-01), Yakel et al.
patent: 2915061 (1959-12-01), Edmondson et al.
patent: 2926121 (1960-02-01), Hobbs et al.
patent: 2963404 (1960-12-01), Hammer et al.
patent: 3114642 (1963-12-01), Meisel
patent: 3169907 (1965-02-01), Heusser et al.
patent: 3172179 (1965-03-01), Schafer
patent: 3192924 (1965-07-01), Edmondson et al.
patent: 3210247 (1965-10-01), Suranyi
patent: 3264115 (1966-08-01), Davis
patent: 3271256 (1966-09-01), Frey
patent: 3341414 (1967-09-01), Cherkas et al.
patent: 3344030 (1967-09-01), Stevens et al.
patent: 3399673 (1968-09-01), Jones et al.
patent: 3418743 (1968-12-01), Halvorsen
patent: 3429308 (1969-02-01), Russell
patent: 3438787 (1969-04-01), Du Ross
patent: 3493652 (1970-02-01), Hartman
patent: 3556811 (1971-01-01), Smith
patent: 3738845 (1973-06-01), Liebrand
patent: 3797494 (1974-03-01), Zaffaroni
patent: 3816953 (1974-06-01), Hameen-Anttila
patent: 3867927 (1975-02-01), Hergott
patent: 3943928 (1976-03-01), Lariccia et al.
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4060084 (1977-11-01), Chandrasekaran et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4139627 (1979-02-01), Lane et al.
patent: 4168308 (1979-09-01), Wretlind et al.
patent: 4169885 (1979-10-01), Raaf et al.
patent: 4225627 (1980-09-01), Moore
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4241092 (1980-12-01), Halik et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4307075 (1981-12-01), Martin
patent: 4311722 (1982-06-01), Vink et al.
patent: 4335147 (1992-06-01), Sollich
patent: 4346709 (1982-08-01), Schmitt
patent: 4372942 (1983-02-01), Cimiluca
patent: 4390520 (1983-06-01), Nagai et al.
patent: 4452825 (1984-06-01), Klacik et al.
patent: 4466953 (1984-08-01), Keith et al.
patent: 4470962 (1984-09-01), Keith et al.
patent: 4482534 (1984-11-01), Blank
patent: 4485087 (1984-11-01), Otsuka et al.
patent: 4517173 (1985-05-01), Kizawa et al.
patent: 4529589 (1985-07-01), Davydov et al.
patent: 4551329 (1985-11-01), Harris et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4588580 (1986-05-01), Gale et al.
patent: 4671953 (1987-06-01), Stanley et al.
patent: 4695463 (1987-09-01), Yang et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4764378 (1988-08-01), Keith et al.
patent: 4818539 (1989-04-01), Shaw et al.
patent: 4863737 (1989-09-01), Stanley et al.
Dyer, "Medicated Candies" 1 Q.S. 4 (1953).
Brown, "Absorption of Analgesics From the Buccal Mucous Membrane", 196 The Practitioner 125 (1966).
Beckett et al., "Buccal Absorption of Basic Drugs and Its Application as an In Vivo Model of Passive Drug Transfer Through Lipid Membranes," 19 J. Pharm. Pharmac, 31S (1967).
Dearden et al., "Buccal Absorption as a Parameter of Analgesic Activity of Some P-Substituted Acetanilides," 23 Journal Pharm. Pharmac. 73S (1971).
Dearden et al., "A New Buccal Absorption Model," 23 J. Pharm. Pharmac., 68S (1971).
Dollery et al., "Differences in the Metabolism of Drugs Depending Upon Their Routes of Administration," 179 Annals of the New York Academy of Sciences 108 (1971).
Dobkin, "Buprenorphine Hydrochloride: Determination of Analgesic Potency," 24 Canadian Anaesthesiology Society Journal 186 (1977).
Edge et al., "Analgesic Effects of Sublingual Buprenorphine," 34 Anaesthesia 463 (1979).
Fry, "Relief of Pain After Surgery," 34 Anaesthesia 549 (1979).
Bullingham et al., "Sublingual Buprenorphine Used Postoperatively: Clinical Observations and Preliminary Pharmacokinetic Analysis," 12 Br. J. Clin. Pharmac. 117 (1981).
Hug et al., "The Pharmacokinetics of Fentanyl," Janssen Pharmaceutical, Inc. (1981).
Ellis et al., "Pain Relief After Abdominal Surgery-A Comparison of I.M. Morphine, Sublingual Buprenorphine and Self-Administer I.V. Pethidine," 54 Br. J. Anaesth. 421 (1982).
Port et al., "Carfentanil: The Primate Experience," American College of Veterinary Anesthesiologist (1983).
Port et al., "Topical Narcotic Anesthesia," to Anesthesiology (1983).
Windholz et al., "The Merck Index," published by Merck & Co., Inc., pp. 575, 795, 796, and Appendix 3 (1983).
Abrams, "New Nitrate Delivery Systems" Buccal Nitroglycerin, vol. 105 American Heart Journal, pp. 848-854 (May 1983).
White et al., "Comparative Pharmacology of Intravenous Anesthetics-A Model for Determining Dosage Requirements and Therapeutic Concentration Ranges During Surgery," 59 Anesthesiology, A379 (Sep. 1983).
Asthana et al., "Verapamil Disposition and Effect on PQ-Intervals After Buccal, Oral and Intravenous Administration," Arzneim.-Forsch./Drug Res., pp. 498-502 (1984).
Derbyshire et al., "Non-Parenteral Postoperative Analgesia," Anesthesia 39, pp. 324-328 (1984).
DeBoer et al., "Drug Absorption by Sublingual and Rectal Routes," 56 British Journal of Anaesthesiology 69 (1984).
Stanley et al., "The Effect of Population Habits on Side Effects and Narcotic Requirements During High-Dose Fentanyl Anaesthesia," 31 Can Anaesth Soc J 3987 (1984).
Bailey et al., "Anesthetic Induction with Fentanyl," 64 Anesthe Analg (1985).
Stanley et al., "Management of Pain and Pain-Related Problems in the Critically Ill Patient," in Critical Care, State of the Art, vol. 6 (1985).
Huttel et al., "Sublingual Flunitrazepam for Premedication," Acta Anaesthesiol Scand. 29, pp. 209-211 (1985).
Risbo et al., "Sublingual Buprenorphine for Premedication and Postoperative Pain Relief in Orthopedic Surgery," Acta Anaesthesiol Scand. 29, pp. 180-182 (1985).
Bell et al., "Buccal Morphine--A New Route for Analgesia?" The Lancet 71 (1985).
Berry, "Premedication and Induction of the Difficult Child" (n.d.).
John D. Ryan, "Premedication, Induction and Parents,"Newsletter Boston, Mass. (n.d.).
"Sublimize (fentanyl) as the Citrate Injection" Product Information (n.d.).
Stanley, "Computer Control of Intravenous Anesthesia," 423.
Schechter et al., "Status of Pediatric Pain Control: A Comparison of Hospital Analgesic Usage in Children and Adults," 77 Pediatrics 11 (186).
Prys-Roberts et al., "Pharmacokinetics of Anaesthesia," Preface.
Bailey et al., "Pharmacology of Intravenous Narcotic Anesthetics," in Anesthesia 2nd ed. (Miller ed. 1986).

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