Compositions of mononuclear phagocytes useful for promoting axon

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

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424 937, 424 931, A01N 6300

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active

061174246

ABSTRACT:
Methods and compositions for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal are disclosed. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. Methods for identifying stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

REFERENCES:
patent: 5078996 (1992-01-01), Conlon, III et al.
patent: 5082670 (1992-01-01), Gage et al.
patent: 5157024 (1992-10-01), Gordon

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