Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1997-07-09
1999-11-23
Naff, David M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
426655, 514885, 514894, A61K 3578
Patent
active
059895560
ABSTRACT:
Compositions derived from Chinese herbal medicines, medicinal plants and extracts thereof, are provided for the treatment of animals infected with viruses, especially with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). More specifically, the compositions of the present invention are derived from various Chinese herbal medicines or medicinal plants which have a long history of human consumption. The compositions of the invention are obtained through specific techniques and have demonstrated outstanding efficacy for treating human HBV carriers and hepatitis C patients. Compositions according to the invention have also exhibited in vitro antiviral activities against murine leukemia virus (MuLV) and HIV. HIV is the virus known to cause acquired immunodeficiency syndrome (AIDS) in humans and AIDS presents special problems to the medical community which the present invention addresses. Preferred compositions contain the herbal ingredients AEGINETIAE HERBA, BLECHNI RHIZOMA, LESPEDEZAE HERBA, POLYGONI CUSPIDATI RHIZOMA, FORSYTHIAE FRUCTUS, and LIGUSTRI FRUCTUS, or contain the herbal ingredients AEGINETIAE HERBA, LONICERAE FLOS, PRUNELLAE SPICA, and LESPEDEZAE HERBA.
REFERENCES:
patent: 4886666 (1989-12-01), Liu
patent: 5178865 (1993-01-01), Ho et al.
patent: 5366725 (1994-11-01), Okubo et al.
patent: 5411733 (1995-05-01), Hozumi et al.
Ghazanfar, Handbook of Arabian Medicinal Plants, CRC Press, Inc., Boca Raton, FLA, pp. 200-202, 1994.
Kugach et al., Khim-Farm ZH, 22:471-475, English translation of abstract only, 1988.
Kikuchi et al., Yakugaku Zasshi, 101:575-578, 1981, English translation of abstract only, 1981.
Junxian et al., Zhongguo Zhongyao Zazhi, 3:168-170, English translation of abstract only, 1990.
Nakanishi et al., Shoyakugaku Zasshi, 47:295-300, 1993.
Tan et al., J. Nat. Prod., 54:143-154, 1991.
Thorne et al., Antiviral Res., 5:335-343, 1985.
D.S. Chen, J. Formos. Med. Assoc., 95(1), 6-12 (1996).
R. P. Perrillo, Digestive Diseases and Sciences, 38(4), 577-593 (1993).
A.S.F. Lok, H. T. Chung, V. W. S. Liu, & O. C. K. Ma, Gastroenterology, 105(6), 1833-1838 (1993).
D.S. Chen, Science, 262, 369-370 (1993).
N. Terrault & T. Wright, New Engl. J. Med., 332(22), 1509-1511 (1995).
B. Jasny, Science, 260(5112), 1219 (1993).
P. Piot, Science, 272(5270), 1855 (1996).
M. I. Johnston & D. F. Hoth, Science, 260(5112), 1286-1293 (1993).
D. D. Richman, Science, 272(5270), 1886-1888 (1996).
R. S. Chang & H. W. Yeung, Antiviral Research, 9, 163-175 (1988).
M. Ito et al., Antiviral Research, 7, 127-137 (1987).
H. Y. Hsu, Y. P. Chen, & M. Hong, The Chemical Constituents of Oriental Herbs, vol. 2, Oriental Healing Arts Institute, Los Angeles, California, U.S.A., 51, 53-55, 142-143, 742, 758-759 (1985).
H. Y. Hsu, Y. P. Chen, S. G. Hsu, J. S. Hsu, C. J. Chen, & H. C. Chang, Concise Pharmacognosy, New Medicine Publishing Co., Taipei, Taiwan, R.O.C., 90, 97, 105-106, 117-118, 126-127, 130-131, 133, 144-145, 152-153, 156-157, 161-162, 174, 176-177, 357-358, 381-382, 384-385, 456-457, 577-578 (1985).
H. Y. Hsu, Y. P. Chen, & M. Hong, The Chemical Constituents of Oriental Herbs, Oriental Healing Arts Institute, Los Angeles, California, U.S.A., 114-115, 249-250, 1400-1401, 1406 (1982).
C.-J. Chou, L.-C. Lin, S.-Y. Hsu, and C.-F. Chen, J. Clin. Med., 4(2), 143-149 (1993).
C.-W. Chang, M.-T. Lin, S.-S. Lee, K.C.S. Liu, F.-L. Hsu, & J.-Y. Lin, Antiviral Research, 27, 367-374 (1995).
P. J. Houghton, Z. Boxu, & Z. Xisheng, Phytother. Res., 7, 384-386 (1993).
J.F. John, R. Kuk, & A. Rosenthal, Abstr. Gen. Meet. Am. Soc. Microbiol., 94, 481 (1994).
K. Yamasaki, T. Otake, H. Mori, M. Morimoto, N. Ueba, Y. Kurokawa, K. Shiota, & T. Yuge, Yakugaku Zasshi, 113(11), 818-824 (1993).
X. J. Yao, M. A. Wainberg, & M. A. Parniak, Virology, 187(1), 56-62 (1992).
H.D. Tabba, R. S. Chang, & K. M. Smith, Antiviral Research, 11, 262-273 (1989).
M. Zheng, J. Tradit. Chin. Med., 8(3), 203-206 (1988).
S. Y. Ryu, C.-K. Lee, C. O. Lee, H. S. Kim, & O. P. Zee, Arch. Pharmacol. Res. (Seoul), 15(3), 242-245 (1992).
Y. L. Lin, Y. H. Kuo, G. H. Lee, and S. M. Peng, J. Chem. Research (S), 320-321 (1987).
T. Nagai, et al., Chem. Pharm. Bull., 38(5), 1329-1332 (1990).
M. Takechi & Y. Tanaka, Planta Medica, 42, 69-74 (1981).
C. J. M. Kane, et al, Bioscience Reports, 8, 85-94 (1988).
H. C. Chang, Medicinal Herbs I, Holiday Publishing Co., Taipei, Taiwan, R.O.C., 15, 36, 100, 113, 127, 147 (1990) (No translation).
H. C. Chang, Medicinal Herbs I, Holiday Publishing Co., Taipei, Taiwan, R.O.C., 15, 131, 135, 155 (1991). (No. translation).
W. S. Kan, Pharmaceutical Botany, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C., 113, 124-130, 200-201, 206-207, 289-290, 353-354, 442-444, 485, 487-488, 497, 505, 513-514, 522, 527-529, 558, 562-563, 648-649 (1971). (No translation).
M. S. Lee, Frequently Used Chinese Crude Drugs and Folk Medicines Handbook, 12th Ed., Sheng-Chang Medicinal Record Magazine Publishing Co., Taipei, Taiwan, R.O.C., 4-6, 17, 21, 29, 36, 38, 40, 48, 64, 71, 79, 85 (1992). (No translation).
Instruction of "Taifu" Serodia-HBs Test Reagent for HBsAg Detection, Taifu Pharmaceutical Co., Ltd., Taoyuan, Taiwan, R.O.C.
D. S. Chen & J. L. Sung, J. Formosan Med. Assoc., 77, 263-270 (1978).
T. Juji & T. Yokochi, Japan, J. Exp. Med., 39, 615-620 (1969).
T. Mosmann, J. Immunological Methods, 65, 55-63 (1983).
H. Ruebsamen-Waigmann, et al., J. Med. Virology, 19, 335-344 (1986).
Ch. Mueller, et al., Fresenius Z. Anal. Chem., 330, 352-353 (1988).
H. V. Briesen, et al., J. Med. Virology, 23, 51-66 (1987).
Instruction of Kyokuto TA-E Transaminase Assay Reagents, Permit No. (62AM)0885, Kyokuto Pharmaceutical Industry Co., Ltd., Tokyo, Japan, 1994.
Instruction of Yatrozyme TA-Lq Transaminase-assay Reagent Solution (Enzyme Assay), Commodity No. 817245 (RM163-K), Yatron Co., Ltd., Diayatron Co., Ltd., Tokyo, Japan.
U. Lippi & G. Guidi, Clin. Chim. Acta., 28, 431-437 (1970).
Hwang Shie-Ming
Tsai Hsiu-Hsien
Kerr Janet M.
Naff David M.
Nickey Donald O.
Sage R&D
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