Compositions of leukaemia inhibitory factor

Details Compositions of leukaemia inhibitory factor Compositions of leukaemia inhibitory factor

2006-10-31

2006-10-31

Canella, Karen A. (Department: 1642)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S085200, C514S008100, C514S021800

Reexamination Certificate

active

07128922

ABSTRACT:
The present invention relates generally to compositions and more particularly to compositions comprising leukaemia inhibitory factor (hereinafter referred to as “LIF”) or derivative or homologues thereof. The compositions of the present invention are particularly useful as compositions which exhibit enhanced stability and/or which exhibit reduced aggregation and/or reduced deamidation of LIF, its derivatives or other active ingredients.

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Cleland, J. L. et al. The development of stable protein formulations: a close look at protein aggregation, deamidatin, and oxidation. Critical Reviews in Therapeutic Drug Carrier Systems 10(4): 307-377, 1993.
Abstract of Van Vlasselaer et al, Prog Growth Factor Res, 1992, vol. 4, pp. 337-353.
Abstract of Taupin et al, Int Rev Immunol, 1998, vol. 16, pp. 397-426.
Abstract of Hilton et al, Journal of Cell Biochemistry, 1991, vol. 46, pp. 21-26.

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