Compositions of leptin bound to an apolipoprotein

Drug – bio-affecting and body treating compositions – Lymphokine

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 530350, 530351, 530402, 530359, 435 71, A61K 3800

Patent

active

058304509

ABSTRACT:
A composition for diagnosing or treating abnormalities in the endogenous leptin pathway in a subject mammal consisting essentially of apolipoprotein J bound to leptin or comprising a purified form of apolipoprotein J bound to leptin. A method for diagnosing abnormalities in the endogenous leptin pathway in a subject mammal. A method for treating abnormalities in the endogenous leptin pathway in a subject mammal. A method for determining the presence or amount of leptin that is associated with apolipoprotein J in a test sample. A kit for performing the method for determining the presence or amount of leptin that is associated with apolipoprotein J in a test sample.

REFERENCES:
Frederich et al, Nature Medicine 12, 1995, p. 1311.
Houscknecht et al, Diabetes 1996, 45, 1638-43.
Sinha et al, J Clin Invest 98(6) 1996, p. 1277.
Campfield et al. Science 269: 546-49, 1995.
Zlokovic et al. Biochem. Biophys Res Comm. 205(2):1431-37, Dec. 15, 1994.
Barinaga, Marcia, "`Obese` Protein Slims Mice," Science 269:475-476 (1995).
Campfield, L. Arthur et al., "Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks," Science 269:546-549 (1995).
Choi-Miura, Nam-Ho, "Beta-Endorphin Binding Activity of SP-40,40," Biol. Pharm. Bull. 16(3):228-231 (1993).
Pelleymounter, Mary Ann et al., "Effects of the obese Gene Product on Body Weight Regulation in ob/ob Mice," Science 269:540-543 (1995).
Jenkins, Sarah H. et al., "Quantitation of Plasma Apolipoprotein J," Methods in Enzymology 263:309-316.
Zlokovic, Berislav V. et al., "Brain Uptake of Circulating Apolipoproteins J and E Complexed to Alzheimer's Amyloid B.sup.1," Biochemical and Biophysical Research Communications 205(2):1431-1437 (1994).
Halaas, Jeffrey L. et al., "Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene," Science 269:543-546 (Jul. 1995).
Maffei, M. et al., "Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects," Nature Medicine 1(11):1155-1161 (Nov. 1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions of leptin bound to an apolipoprotein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions of leptin bound to an apolipoprotein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions of leptin bound to an apolipoprotein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-686605

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.