Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1994-02-01
1995-11-21
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
514506, 558 51, 558 53, 558 54, A61K 4904
Patent
active
054684668
ABSTRACT:
Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene, lower-alkoxy-carbonyloxy;
REFERENCES:
patent: 2348231 (1944-05-01), Strain et al.
patent: 2622100 (1952-12-01), Newbery et al.
patent: 3360436 (1967-12-01), Felder et al.
patent: 3361700 (1968-01-01), Archer et al.
patent: 3574718 (1971-04-01), Bjork et al.
patent: 3795698 (1974-03-01), Soulal et al.
patent: 3825591 (1974-07-01), Felder et al.
patent: 4835304 (1989-05-01), Williams
Wentworth, SE et al., Organic Preparation and Procedures, 1(4):225-228 (1969).
Schmidt, B, et al. Chem. Ber. 125(6):1501-1506, (1992).
Motherwell, WB et al. J. Chem. Soc. Chem. Commun. (13):877-879 (1991).
Fu, JM et al. Tetrahedron Letters, 31(12):1665-1668 (1990).
Matsumoto, T et al., Tetrahedron Letters, 32(46):6735-6736 (1991).
Echavarren, AM et al. J. American Chemical Society, 109(18):5478-5486 (1987).
Matsumoto, T et al., Synlett (11):843-846 (1993).
Yoshikawa, T. et al, Chem. Abst, 70(1):3539 pp. 318-319 (1969).
Bacon Edward R.
Daum Sol J.
Douty Brent D.
Estep Kimberly G.
Illig Carl R.
Hollinden Gary E.
Sterling Winthrop Inc.
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