Compositions of iodophenyl esters and iodophenyl sulfonates and

Details Compositions of iodophenyl esters and iodophenyl sulfonates and Compositions of iodophenyl esters and iodophenyl sulfonates and

1994-05-26

1995-12-05

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

514 57, 514546, 514548, 514552, A61K 4904, A61K 3122

Patent

active

054726824

ABSTRACT:
Disclosed are x-ray contrast compositions of the formula ##STR1## wherein X is ##STR2## or --SO.sub.2 --; Z is H, halo, methyl, ethyl, n-propyl, C.sub.4 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R is C.sub.1 -C.sub.25 alkyl, cycloalkyl or aryl each of which may be optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy;
n is 1-5;
y is 0-4; and
w is 1-4;
in combination with a pharmaceutically acceptable clay; and method for their use in diagnostic radiology of the gastrointestinal tract.

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