Compositions of ezetimibe and methods for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S183000, C514S210020, C514S324000, C514S414000, C514S618000, C514S645000, C514S651000

Reexamination Certificate

active

07098198

ABSTRACT:
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent. An article of manufacture is also provided which comprises a container, instructions, and a composition, wherein the composition comprises a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe or its phenolic glucuronide, and the instructions are for the administration of the composition for the prevention or treatment of a cholesterol-associated tumor.

REFERENCES:
patent: 6534540 (2003-03-01), Kindness et al.
patent: 2001/0041713 (2001-11-01), Waldstreicher et al.
patent: WO 93/02048 (1993-02-01), None
patent: WO 94/17038 (1994-08-01), None
patent: WO 95/08532 (1995-03-01), None
Webster's II New Riverside University Dictionary, published 1984, see pp. 933 and 1208.
Hawk et al., Primary Cancer Prevention Trails, Hematology/Oncology Clinics of North America, vol. 14, No. 4, Aug. 2000, pp. 809-830.

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