Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-23
2005-08-23
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S171000, C514S183000, C514S324000, C514S414000, C514S618000, C514S645000, C514S651000
Reexamination Certificate
active
06933292
ABSTRACT:
A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent. An article of manufacture is also provided which comprises a container, instructions, and a composition, wherein the composition comprises a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe or its phenolic glucuronide, and the instructions are for the administration of the composition for the prevention or treatment of a cholesterol-associated tumor.
REFERENCES:
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patent: 5919815 (1999-07-01), Bradley et al.
patent: 6534540 (2003-03-01), Kindness et al.
patent: 2001/0041713 (2001-11-01), Waldstreicher et al.
patent: WO 93/02048 (1993-02-01), None
patent: WO 94/17038 (1994-08-01), None
patent: WO 95/08532 (1995-03-01), None
Freeman Michael R.
Schaffner Carl P.
Solomon Keith R.
Children's Medical Center Corporation
Fox Rothschild LLP
Henley III Raymond J.
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