Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2006-01-19
2009-11-17
Mosher, Mary E (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C424S221100, C424S218100, C536S023720, C435S320100, C435S236000
Reexamination Certificate
active
07618802
ABSTRACT:
The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are methods of making the compositions of this invention and methods of using the compositions as immunogens and/or vaccines and/or to express heterologous nucleic acids.
REFERENCES:
patent: WO 99/29872 (1999-06-01), None
Pasternak et al (Journal of General Virology 87:1403-1421, 2006).
Zuniga et al (Journal of Virology 78:980-994, Jan. 2004).
Gorbalenya et al (Virus Research 117:17-37, 2006).
van Marle et al (PNAS 96:12056-12061, 1999).
Smits et al (Journal of Virology 79:8275, 2005).
Draker et al (Virus Research 115:56-68, 2006, available online Aug. 30, 2005).
Genbank locus AY427798, “Breda virus strain Breda 1, complete genome” (Dec. 15, 2005).
International Search Report for PCT/US04/23548, mailed Oct. 18, 2006.
Marra et al. “The Genome Sequence of the SARS-Associated Coronavirus”Science300:1399-1404 (2003).
Rota et al. “Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome”Science300:1394-1399 (2003).
Xu et al. “Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis”Acta Pharmacol ,Sin24(6):505-511 (2003).
Agapov et al. “Noncytopathic Sindbis virus RNA vectors for heterologous gene expression”Proc. Natl. Acad. Sci. USA 98:12989-12994 (1998).
Almazan et al. “Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome”PNAS 97(10):5516-5521 (2000).
Balasuriya et al. “Expression of the Two Major Envelope Proteins of Equine Arteritis Virus as a Heterodimer Is Necessary for Induction of Neutralizing Antibodies in Mice Immunized with Recombinant Venezuelan Equine Encephalitis Virus Replicon Particles”J. Virol. 74(22):10623-10630 (2000).
Baudoux et al. “Coronavirus Pseudoparticles Formed with Recombinant M and E Proteins Induce Alpha Interferon Synthesis by Leukocytes”J. Virol. 72(11):8636-8643 (1998).
Berglund et al. “Enhancing immune responses using suicidal DNA vaccines”Nature Biotechnology 16:562-565 (1998).
Bos et al. “The Production of Recombinant Infectious DI-Particles of a Murine Coronavirus in the Absence of Helper Virus”Virology 218:52-60 (1996).
Bredenbeek et al. “Sindbis Virus Expression Vectors: Packaging of RNA Replicons by Using Defective Helper RNAs”J. Virol. 67(11):6439-6446 (1993).
Caley et al. “Humoral, Mucosal, and Cellular Immunity in Response to a Human Immunodeficiency Virus Type 1 Immunogen Expressed by a Venezuelan Equine Encephalitis Virus Vaccine Vector”J. Virol. 71(4):3031-3038 (1997).
Curtis et al. “A Simple Strategy to Assemble Infectious RNA and DNA Clones”Adv. Exp. Med. Biol. 494:475-481 (2001).
Curtis et al. “Coronavirus Derived Vectors for Genetic Analysis and Heterologous Gene Expression”Recent Res. Devel. Virol.4:203-229 (2002).
Curtis et al. “Heterologous Gene Expression from Transmissible Gastroenteritis Virus Replicon Particles”J. Virol. 76(3):1422-1434 (2002).
Curtis et al. “Reverse Genetic Analysis of the Transcription Regulatory Sequence of the Coronavirus Transmissible Gastroenteritis Virus”J. Virol. 78(11):6061-6066 (2004).
de Haan et al. “Coronavirus Particle Assembly: Primary Structure Requirements of the Membrane Protein”J. Virol 72(8):6838-6850 (1998).
DiCiommo et al. “Rapid, High Level Protein Production Using DNA-based Semliki Forest Virus Vectors”The Journal of Biological Chemistry 273(29):18060-18066 (1998).
Dollenmaier et al. “Membrane-Associated Respiratory Syncytial Virus F Protein Expressed from a Human Rhinovirus Type 14 Vector Is Immunogenic”Virology 281:216-230 (2001).
Dubensky et al. “Sindbis Virus DNA-Based Expression Vectors: Utility for In Vitro and In Vivo Gene Transfer”J. Virol. 70(1):508-519 (1996).
Fischer et al. “Analysis of a Recombinant Mouse Hepatitis Virus Expressing a Foreign Gene Reveals a Novel Aspect of Coronavirus Transcription”J. Virol. 71(7):5148-5160 (1997).
Fischer et al. “Analysis of Constructed E Gene Mutants of Mouse Hepatitis Virus Confirms a Pivotal Role for E Protein in Coronavirus Assembly”J. Virol. 72(10):7885-7894 (1998).
Fuerst et al. “Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase”Proc. Natl. Acad. Sci. USA 83:8122-8126 (1986).
Godeke et al. “Assembly of Spike into Coronavirus Particles Is Mediated by the Carboxy-Terminal Domain of the Spike Protein”J. Virol. 74(3):1566-1571 (2000).
Hevey et al. “Marburg Virus Vaccines Based upon Alphavirus Replicons Protect Guinea Pigs and Nonhuman Primates” 251:28-37 (1998).
International Search Report, PCT/US02/12453, Mar. 13, 2003.
Khromykh et al. “Subgenomic Replicons of the Flavivirus Kunjin: Construction and Applications”Journal of Virology 71(2):1497-1505 (1997).
Khromykh, A.A. “Replicon-based vectors of positive strand RNA viruses”Current Opinion in Molecular Therapeutics 2(5):555-569 (2000).
Liljestrom et al. “A New Generation of Animal Cell Expression Vectors Based On The Semliki Forest Virus Replicon”Biotechnology 9:1356-1361 (1991).
Mendez et al. “Molecular Characterization of Transmissible Gastroenteritis Coronavirus Defective Interfering Genomes: Packaging and Heterogeneity”Virology 217:495-507 (1996).
Messerle et al. “Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome”Proc. Natl. Acad. Sci. USA 94:14759-14763 (1997).
Meulenberg et al. “Infectious Transcripts from Cloned Genome-Length cDNA of Porcine Reproductive and Respiratory Syndrome Virus”J. Virol. 72(1):380-387 (1998).
Ortego et al. “Generation of a Replication-Competent, Propagation-Deficient Virus Vector Based on the Transmissible Gastroenteritis Coronavirus Genome”J. Virol. 76(22):11518-11529 (2002).
Percy et al. “A Poliovirus Replicon Containing the Chloramphenicol Acetyltransferase Gene Can Be Used To Study the Replication and Encapsidation of Poliovirus RNA”J. Virol. 66(8):5040-5046 (1992).
Porter et al. “Encapsidation of Genetically Engineered Poliovirus Minireplicons Which Express Human Immunodeficiency Virus Type 1 Gag and Pol Proteins upon Infection”J. Virol. 67(7):3712-3719 (1993).
Pushko et al. “Replicon-Helper Systems from Attenuated Venezuelan Equine Encephalitis Virus: Expression of Heterologous Genes in Vitro and Immunization against Heterologous Pathogens in Vivo”Virology 239:389-401 (1997).
Schutz-Cherry et al. “Influenza (A/HK/156/97) Hemagglutinin Expressed by an Alphavirus Replicon System Protects Chickens against Lethal Infection with Hong Kong-Origin H5N1 Viruses”Virology 278:55-59 (2000).
Varnavski et al. “Stable High-Level Expression of Heterologous Genes In Vitro and In Vivo by Noncytopathic DNA-Based Kunjin Virus Replicon Vectors”J. Virol. 74(9):4394-4403 (2000).
Vennema et al. “Intracellular Transport of Recombinant Coronavirus Spike Proteins: Implications for Virus Assembly”J. Virol. 64(1):339-346 (1990).
Vennema et al. “Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes”The EMBO Journal 15(8):2020-2028 (1996).
Yount et al. “Strategy for Systematic Assembly of Large RNA and DNA Genomes: Transmissible Gastroenteritis Virus Model”J. Virol. 74(22):10600-10611 (2000).
Yount et al. “Biological consequences of TGEV Gene Rearrangement” 20thAnnual American Society for Virology Meeting, Madison, WI (Jul. 21-25, 2001) (Abstract).
Yount et al. “Coronavirus Heterologous Gene Expression Vectors” Six
Baric Ralph S.
Curtis Kristopher M.
Roberts Rhonda
Yount Boyd
Mosher Mary E
Myers Bigel Sibley & Sajovec P.A.
The University of North Carolina at Chapel Hill
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