Compositions of arginine amide with cyclodextrin of caffeine, an

Details Compositions of arginine amide with cyclodextrin of caffeine, an Compositions of arginine amide with cyclodextrin of caffeine, an

1996-04-05

1997-02-25

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514187, 514263, 544274, 536103, 546172, A61K 31715, A61K 31555, A61K 3152

Patent

active

056058926

ABSTRACT:
An aqueous agent comprising at least one arginine amide selected from the group consisting of (2R,4R)-4-methyl-1-[N.sup.2 -((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piper idinecarboxylic acid, monohydrate thereof and pharmacologically acceptable salts thereof, and at least one compound selected from the group consisting of cyclodextrin and caffeine; a method for improving the solubility of arginine amide in water, comprising adding at least one compound selected from the group consisting of cyclodextrin and caffeine; and a method for stabilizing arginine amide in water, comprising adding caffeine. According to the present invention, the solubility of arginine amide in water can be enhanced to, for example, a concentration permitting inhibition of fibrin formation at the time of entoptic operation. In addition, the stability of arginine amide in water can be enhanced with less irritation of the eye.

REFERENCES:
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patent: 4517995 (1985-05-01), Lyles
patent: 4728509 (1988-03-01), Shimizu et al.
patent: 5024998 (1991-06-01), Bodor
patent: 5180747 (1993-01-01), Matsuda et al.
patent: 5256316 (1993-10-01), Suzuki et al.
patent: 5324718 (1994-06-01), Loftsson
patent: 5356897 (1994-10-01), Oku et al.
Herrman et al. Drugs Jul. 1993, 46(1), 18-52.

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