Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-12-26
2006-12-26
Chism, B. Dell (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S326000, C530S344000, C435S383000
Reexamination Certificate
active
07153832
ABSTRACT:
Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.
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Genbank accession: AK013218.
Genbank accession: NP—003382.1.
Genbank accession: NP—003383.1.
Genbank accession: NP—003384.1.
Genbank accession: NP—003385.2.
Genbank accession: NP—003386.1.
Genbank accession: NP—003387.1.
Genbank accession: NP—004176.2.
Genbank accession: NP—004616.2.
Genbank accession: NP—004617.2.
Genbank accession: NP—005421.1.
Genbank accession: NP—006513.1.
Genbank accession: NP—057171.2.
Genbank accession: NP—078613.1.
Genbank accession: NP—079492.2.
Genbank accession: NP—110380.1.
Genbank accession: NP—110388.2.
Genbank accession: NP—114139.1.
Genbank accession: NP—476509.1.
Genbank accession: NP—478679.1.
Genbank accession: NP—490645.1.
Genbank accession: X56842.
Hsieh et al., Biochemical Characterization of Wnt-Frizled Interactions Using a Soluble, Biologically Active Vertebrate Wnt Protein, Proc Natl Acad Sci, 1999, 96(7):3546-51.
Nusse et al., Many Tumors Induced Y the Mouse Mammary Tumor Virus Contain a Provirus Integrated in the Same Region of the Host Genome, Cell, 1982, 31:99-109.
Van Leeuwen et al., Biological Activity of Soluble Wingless Protein in Cultured Drosophila Imaginal Disc Cells, Nature, 1994, 24:368(6469):342-4.
Nusse Roeland
Willert Karl H.
Boziecevic, Field & Francis LLP
Chism B. Dell
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
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