Compositions, methods and devices for maintaining an organ

Details Compositions, methods and devices for maintaining an organ Compositions, methods and devices for maintaining an organ

2005-10-11

2005-10-11

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

C435S001200, C435S001300

Reexamination Certificate

active

06953655

ABSTRACT:
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.

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Merck Index, Eleventh Edition 1989, entry 4353.
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Dobrian et al., “In vitro formation of oxidatively-modified and reassembled human low-density lipoproteins Antioxidant effect of albumin”, BBA 1169 :12-24 (1993).
Birkett et al., “The fatty-acid content and drug binding characteristics of commercial albumin preparations”, Clin. Chem. Acta 85 (3): 253-258 (1978).
Watanabe et al., “Effects of free fatty acids on the binding of bovine and human serum albumin with steroid hormones”, BBA 1289: 385-396 (1996).

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