Compositions, methods and devices for maintaining an organ

Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus

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4352866, 4352865, A01N 102

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active

060460466

ABSTRACT:
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.

REFERENCES:
patent: 3738914 (1973-06-01), Thorne et al.
patent: 5472876 (1995-12-01), Fahy
patent: 5494822 (1996-02-01), Sadri
patent: 5498427 (1996-03-01), Menasche
patent: 5586438 (1996-12-01), Fahy
patent: 5599173 (1997-02-01), Chen et al.
patent: 5716378 (1998-02-01), Minten
patent: 5786136 (1998-07-01), Mayer
patent: 5807737 (1998-09-01), Schill et al.
Chien, et al., "Canine Lung Transplantation After More Than Twenty-four Hours of Normothermic Preservation," The Journal of Heart and Lung Transplantation, vol. 16, No. 3, Mar. 1997, pp. 340-351.
Chien, et al., "Functional Studies of the Heart During a 24-Hour Preservation Using a New Autoperfusion Preparation," The Journal of Heart and Lung Transplantation, vol. 10, No. 3, May/Jun. 1991, pp. 401-408.
Chien, et al., "A Simple Technique For Multiorgan Preservation," The Journal of Thoracic and Cardiovascular Surgery, vol. 95, No. 1, Jan. 1988, pp. 55-61.
Philippe Menasche, et al., "Improved Recovery of Heart Transplants With A Specific Kit of Preservation Solutions," The Journal of Thoracic and Cardiovascular Surgery, vol. 105, No. 2, Feb. 1993, pp. 353-363.
Vinten-Johansen, et al., "Reduction in Surgical Ischemic-Reperfusion Injury With Adenosine and Nitric Oxide Therapy," Annals of Thoracic Surgery, No. 60, 1995, pp. 852-857.
Lasley, et al., "Protective Effects of Adenosine in the Reversibly Injured Heart," Annals of Thoracic Surgery, No. 60, 1995, pp. 843-846.
Wicomb, et al., "Cardiac Transplantation Following Storage of the Donor Heart by a Portable Hypothermic Perfusion System," The Annals of Thoracic Surgery, vol. 37, No. 3, Mar. 1984, pp. 243-248.
Hardesty, et al., "Autoperfusion of the Heart and Lungs For Preservation During Distant Procurement," The Journal of Thoracic and Cardiovascular Surgery, vol. 93, No. 1, Jan. 1987, pp. 11-18.
Calhoon, et al., "Twelve-Hour Canine Heart Preservation With a Simple, Portable Hypothermic Organ Perfusion Device," Annals of Thoracic Surgery, No. 62, 1996, pp. 91-93.
Rao, et al., "Donor Blood Perfusion Improves Myocardial Recovery After Heart Transplantation," The Journal of Heart and Lung Transplantation, vol. 16, No. 6, Jun. 1997, pp. 667-673.
Burt, et al., "Myocardial Function After Preservation For 24 Hours," The Journal of Thoracic and Cardiovascular Surgery, vol. 92, No. 2, Aug. 1986, pp. 238-246.
Wicomb, et al., "Orthotopic Transplantation of the Baboon Heart After 20 to 24 Hours' Preservation By Continuous Hypothermic Perfusion With An Oxygenated Hyperosmolar Solution," The Journal of Thoracic and Cardiovascular Surgery, vol. 83, No. 1, Jan. 1992, pp. 133-140.
Chambers, et al., "Long-Term Preservation of the Heart: The Effect of Infusion Pressure During Continuous Hypothermic Cardioplegia," The Journal of Heart and Lung Transplantation, vol. 11, No. 4, Part 1, Jul./Aug. 1992, pp. 665-675.
Yland, et al., "New Pulsatile Perfusion Method for Non-Heart-Beating Cadaveric Donor Organs: A Preliminary Report," Transplantation Proceedings, vol. 25, No. 6, Dec. 1993, pp. 3087-3089.
Segel, et al., "Posttransplantation Function of Hearts Preserved With Fluorochemical Emulsion," The Journal of Heart and Lung Transplantation, vol. 13, No. 4, Jul./Aug. 1994, pp. 669-680.
Pearl, et al., "Loss of Endothelium-Dependent Vasodilatation and Nitric Oxide Release After Myocardial Protection With University of Wisconsin Solution," The Journal of Thoracic and Cardiovascular Surgery, vol. 107, No. 1, Jan. 1994, pp. 257-264.
Lefer, et al., "Attenuation of Myocardial Ischemia-Reperfusion Injury With Nitric Oxide Replacement Therapy," Annals of Thoracic Surgery, No. 60, 1995, pp. 847-851.
Seccombe, et al., "Coronary Artery Endothelial Function After Myocardial Ischemia and Reperfusion," Annals of Thoracic Surgery, No. 60, 1995, pp. 778-787.
Hartman, J. Craig, "The Role of Bradykinin and Nitric Oxide in the Cardioprotective Action of ACE Inhibitors," Annals of Thoracic Surgery, No. 60, 1995, pp. 789-792.
Rinder, et al., "Blockade of C5a and C5b-9 Generation Inhibits Leukocyte and Platelet Activation During Extracorporeal Circulation," The Journal of Clinical Investigation, Inc., vol. 96, Sep. 1995, pp. 1564-1572.
Aoki, et al., "Anti-CD18 Attenuates Deleterious Effects of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest in Piglets," J Card Surg, vol. 10, 1995, pp. 407-417.
Rosenkranz, Eliot R., "Substrate Enhancement of Cardioplegic Solution: Experimental Studies and Clinical Evaluation," Annals of Thoracic Surgery, vol. 60, 1995, pp. 797-800.
Engelman, et al., "Influence of Steroids On Complement and Cytokine generation After Cardiopulmonary Bypass," Annals of Thoracic Surgery, vol. 60, 1995, pp. 801-804.
Boyle, et al., "Ischemia-Reperfusion Injury," Annals of Thoracic Surgery, vol. 64, 1997, pp. 524-530.
Li, et al., "Functional Recovery In Rabbit Heart After Preservation With a Blood Cardioplegic Solution and Perfusion," The Journal of Heart and Lung Transplantation, vol. 12, No. 2, Mar./Apr. 1993, pp. 263-270.
Seccombe, et al., "Coronary Artery Endothelial Function After Myocardial Ischemia and Reperfusion," Annals of Thoracic Surgery, vol. 60, 1995, pp. 778-788.
Mankad, et al., "Endothelial Dysfunction Caused By University of Wisconsin Preservation Solution In the Rat Heart," The Journal of Thoracic and Cardiovascular Surgery, vol. 104, No. 6, Dec. 1992, pp. 1618-1624.
Sunamori, et al., "Relative Advantages of Nondepolarizing Solution to Depolarizing University of Wisconsin Solution in Donor Heart Preservation," Transplantation Proceedings, vol. 25, No. 1, Feb. 1993, pp. 1613-1617.
Pinsky, et al., "Restoration of the cAMP Second Messenger Pathway Enhances Cardiac Preservation for Transplantation in a Heterotopic Rat Model," The American Society for Clinical Investigation, Inc., vol. 92, Dec. 1993, pp. 2994-3002.
Richens, et al., "Clinical Study of Crystalloid Cardioplegia vs Aspartate-Enriched Cardioplegia Plus Warm Reperfusion For Donor Heart Preservation," Transplantation Proceedings, vol. 25, No. 1, Feb. 1993, pp. 1608-1610.
Finn, et al., "Effects of Inhibition of Complement Activation Using Recombinant Soluble Complement Receptor 1 On Neutrophil CD11B/CD18 and L-Selectin Expression and Release of Interleukin-8 and Elastase In Simulated Cardiopulmonary Bypass," The Journal of Thoracic and Cardiovascular Surgery, vol. 111, No. 2, Feb. 1996, pp. 451-459.
Wicomb, et al., "24-Hour Rabbit Heart Storage With UW Solution," Transplantation Proceedings, vol. 48, No. 1, Jul. 1989, pp. 6-9.
Menasche, et al., "Experimental Evaluation of Celsior.RTM., A New Heart Preservation Solution," European Journal of Cardiothoracic Surgery, vol. 8, 1994, pp. 207-213.
Ferrera, et al., "Comparison of Different Techniques of Hypothermic Pig Heart Preservation," Annals of Thoracic Surgery, vol. 57, 1994, pp. 1233-1239.
Gundry, et al., "Successful Transplantation of Hearts Harvested 30 Minutes After Death From Exsanguination," Annals of Thoracic Surgery, vol. 53, 1992, pp. 772-775.
Demertzis, et al., "University of Wisconsin Versus St. Thomas' Hospital Solution For Human Donor Heart Preservation," Annals of Thoracic Surgery, vol. 55, 1993, pp. 1132-1137.
Segel, et al., "Recovery of Sheep Hearts After Perfusion Preservation or Static Storage With Crystalloid Media," The Journal of Heart and Lung Transplantation, vol. 17, No. 2, Feb. 1998, pp. 211-221.
The DuPont Merck Pharmaceutical Co., Product Literature For "ViaSpan.RTM. (BELZER UW) Cold Storage Solution," Jan. 1996.
Drexler, et al., "Effect of L-Arginine On Coronary Endothel

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