Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-10-17
2006-10-17
Prouty, Rebecca E. (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S019000, C435S069100, C435S006120, C435S320100, C435S325000, C435S196000, C514S007600, C514S929000, C514S930000, C536S023200
Reexamination Certificate
active
07122655
ABSTRACT:
The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hypertension or hypertensive conditions by administering to a mammal a therapeutically effective amount of an agent that reduces the level or activity of M-RIP. According to this invention, the agent decreases contractile and increases relaxant effects of smooth muscle cells, ultimately decreasing the systemic blood pressure of a mammal. For example, the agent may reduce binding of M-RIP to myosin phosphatase, RhoA, or both.
REFERENCES:
Surk's H.K., Richards, C.T. and Mendelsoon M.E. Myosin Phosphatase Rho-interacting protein: New members of the myosin phosphatase complex that directly bins RhoA. J. Biolo. Chem. 278 (51), 51484-51493 (2003).
Inazawa et al., Cloning of human orthologue RHOIP3 of Mus Rhoip3, GenBank accession No. AB098507 (Jun. 21, 2003).
Ottenwaelder et al., GeneBank submission AL834513 Jul. 12, 2002.
Yue H. et al., Human intracellular signaling molecules INTSIG-24 cDNA. ADA13387 with a provisional filing date of Sep. 14, 2001 (2001US-0322188P) sequence No.: 17.
Diekmann et al., “In Vitro Binding Assay for Interactions of Rho and Rac with GTPase-Activating Proteins and Effectors,”Methods Enzymol, 256:207-215 (1995).
Gebbink et al., “Identification of a Novel, Putative Rho-Specific GDP/GTP Exchange Factor and a RhoA-Binding Protein: Control of Neuronal Morphology,”J. Cell Biol. 137:1603-1613 (1997).
Mulder et al., “p116Ripis a Novel Filamentous Actin-Binding Protein,”J. Biol. Chem. 278:27216-27223 (2003).
Surks et al., “Myosin Phosphatase-Rho Interacting Protein. A New Member of Myosin Phosphatase Complex That Directly Binds RhoA,”J. Biol. Chem. 278:51484-51493 (2003).
Mendelsohn Michael E.
Surks Howard K.
Clark & Elbing LLP
Gebreyesus Kagnew
New England Medical Center Hospital, Inc.
Prouty Rebecca E.
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