Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1988-01-04
1993-06-15
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 9, A61K 4904, A61K 4900
Patent
active
052195520
DESCRIPTION:
BRIEF SUMMARY
The method of X-ray tomo-densitometry is an exploring and imaging process of the human body which allows inter alia the evidencing of full organs.
The study of the abdominal organs in X-ray tomo-densitometry needs the use of contrast agents for a better identification of the anatomical features.
So through the endovenous injection of water-soluble iodinated compounds called Angio-scan, it has been possible to evidence the vessels as well as the parenchym of full organs (liver, spleen..).
The hollow organs are difficult to investigate in spite of the use of very diluted iodinated compounds given by oral way. Their optical density on one hand and their lack of homogeneity on the other hand is why they failed to respond to the hopes expressed for the anatomical indentification and diagnosis of pathological elements.
The utilization of new constrast agents based on concentrated solutions of metals such as calcium, magnesium or zinc reply to the above-cited criticisms: hour without leaving an anatomical empty space. anatomical or anatomopathological element in the vicinity. tract.
The compositions according to this invention are solutions in water or in an aqueous medium compatible with the body fluids, containing at least a salt of a metal having an atomic weight comprised between 24 and 66 or a complex of Cobalt or Zinc with a chelating agent.
Among the above-defined metals they may be more particularly be cited derivatives of Magnesium, derivatives of Calcium, derivatives of Manganese, derivatives of Iron, derivatives of Zinc and derivatives of Cobalt.
The salts which are used are those soluble in water and allowing to realize concentrated solutions having from 5 to 25% of the metallic derivative.
To this end, it will be preferably used, a chloride, a nitrate, sulphate, an acetate, and especially a metallic gluconate, lactobionate, glucoheptonate or gluconoglucoheptonate.
So it will be advantageous to use a solution of magnesium chloride, of calcium nitrate, of ferrous gluconate, of calcium lactobionate, of calcium gluconoglucoheptonate, of zinc sulphate, of manganese actate, or of magnesium formate.
It may also be advantageous in the case of Cobalt or Zinc derivatives, to use them in the form of complexes soluble in water such as those of Ethylenediaminotetracetic acid, those of Ethyleneglycol bis ( -aminoethylether) N,N, N',N'-tetracetic acid, those of ethylenediamine NN-diacetic N',N'-di-propionic acid or those of ethylene diamine NN-diacetic N'N'-di- propionic acid. These complexes may more precisely be constituted of mixed molecules containing from two to four alkali metal ions as for example the complexe of ethylenediamine tetracetic acid with zinc in the form of tetra sodium salt.
The use of these complexes, includes the advantage of having a limited taste, and a lack of toxicity.
The solutions according to this invention may also be admixed with a thickening agent, an agent which increases the viscosity, a sweetening agent, a flavouring agent.
The solutions are intended to be given orally in the form of a solute, a syrup or a potion; rectally as an enema or by endocavitar way as for example by instillation in the bladder or the urogenital tract.
In a preferred manner one utilizes an aqueous solution containing 5, 10 or 15% of a salt of a metal the atomic weight of which is comprised between 24 and 66, sweetened with a synthetic sweetining agent such as Aspartame or a saccharinate as for example the to sodium or the calcium derivative.
They may also be utilized mixed solutions which contain a mixture of the above cited metallic derivatives in a respective ratio ranging from 1 to 99% as for example a solution containing equal parts of a magnesium salt and a calcium salt. These salts may be derived from the same anion or, except for chemical unsuitability, from two different anions.
For examination of the organs and namely those of the digestive tract, the compositions according to this invention may moreover include a drug which modifies the motility, and preferably a drug which decreases or suppress t
REFERENCES:
patent: 3542915 (1970-11-01), Bodkin
patent: 3832457 (1974-08-01), Sugimoto et al.
patent: 4423158 (1983-12-01), Porath
patent: 4647447 (1987-03-01), Gries et al.
patent: 4885363 (1989-12-01), Tweedle et al.
Skucas, Jovitas "Agents in computed Tomography", Radiographic Contrast Agents, pp. 109-116.
Dietlin Francois
Heitz Fernand
Waddell Frederick E.
Weddington K.
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