Compositions inhibiting estrogen sulfotransferase activity

Details Compositions inhibiting estrogen sulfotransferase activity Compositions inhibiting estrogen sulfotransferase activity

1983-05-18

1989-03-07

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514843, A61K 3156

Patent

active

048107000

ABSTRACT:
An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R.sub.1 is F, Br, NO.sub.2, or H; R.sub.2 is F, Br, NO.sub.2, NH.sub.2, or H; R is H or alkyl of 1-4 carbon atoms; R.sub.3 is O or H.sub.2 ; and R.sub.4 is H.sub.2, O, or .alpha.-H, .beta.-OH; R.sub.5 is H.sub.2, .alpha.-H and .beta.-OH or B-H and .alpha.-OH in admixture with a pharmaceutically acceptable carrier with the proviso that R.sub.1, R.sub.2 and R.sub.3 cannot all be hydrogen and one of R.sub.1 and R.sub.2 is F.

REFERENCES:
Utne et al., "Journal of Organic Chemistry", Jun. (1968), pp. 2469-2473.

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