Compositions inhibiting estrogen sulfotransferase activity

Details Compositions inhibiting estrogen sulfotransferase activity Compositions inhibiting estrogen sulfotransferase activity

1978-10-18

1982-07-20

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424243, A01N 4500, A61K 3156

Patent

active

043406025

ABSTRACT:
An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R.sub.1 is Br, NO.sub.2, or H; R.sub.2 is Br, NO.sub.2, NH.sub.2, or H; R is H or alkyl of 1-4 carbon atoms; R.sub.3 is O or H.sub.2 ; and R.sub.4 is H.sub.2, O, or .alpha.-H, .beta.-OH, in admixture with a pharmaceutically acceptable carrier. The specificity of the invention is believed targeted to the substituent at R.sub.2 or C.sub.4 and secondarily the OR group at C.sub.3.

REFERENCES:
patent: 3251833 (1966-05-01), Cantrall et al.
patent: 3813418 (1974-05-01), Hofmeister et al.
patent: 3939186 (1976-02-01), Wakabayashi et al.
Rozkin et al., "Jour. Biol. Chemistry", vol. 252, No. 20 (1977), pp. 7214-7220.
Tomson et al., "Journal of Org. Chem." (1959), No. 24, pp. 2056-2058.

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