Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-01-20
2000-04-04
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514247, 514248, 514249, 514255, 514292, A61K 31395, A61K 31495, A61K 3150
Patent
active
060462000
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are alkyl of 1-8 carbons have been shown to have both neuroprotective and analgesic activities. The compounds of the invention may be used in treatment of conditions that would normally result in neuronal damage, including those arising on account of cerebral ischemia/hypoxia or increase in intracranial pressure such as neoplasms, stroke, meningitis or trauma. Compositions of the invention can also be useful for treatment of toxin-related damage such as drug over-dose or exposure to toxins in the environment.
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Calderon Sylvia N.
DeCoster Mark A.
Rice Kenner C.
Tortella Frank C.
Harris Charles H.
Harrison Robert H.
The United States of America as represented by the Department of
The United States of America as represented by the Secretary of
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