Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-07-06
1997-06-17
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514 701, 514677, 514682, 514719, 514880, A51K 3578
Patent
active
056394594
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to topical compositions for the treatment of the hair which comprise a pharmaceutically acceptable oxalate of a group Ia or IIa metal or ammonium oxalate, disposed in a pharmaceutical acceptable carrier or diluent therefor. The pharmaceutically acceptable oxalate is preferably an oxalate selected from calcium, barium or magnesium, lithium, sodium or potassium and may include an organic plant derived oxalate.
Extracts of red and white squill have long been reported to have medicinal properties; white squill having the property of being a cardiac stimulant, a diuretic or emetic. These extracts have been utilised for this purpose for very many years.
We have previously described how both red and white squill extracts are useful for restoring hair loss due to conditions such as alopecia whether or not problems of seborrhoea exist.
The applicant has now found that a significant component of this composition, in so far as hair treatment is concerned are calcium oxalate crystals derived from the squill extract, optionally with at least some of the mucilage associated therewith.
Further tests revealed, however that the active principle of such pharmaceutical compositions was a group Ia or IIa metal oxalate, optionally with an organic oxalate and/or mucilage derived from a plant extract.
In canadian patent 888689 there is disclosed the use of a composition for the treatment for the scalp against hair loss which essentially requires the use of an emulsion comprising bergamot oil, water and a ferrous salt including a ferrous oxalate (i.e. a group VIII metal salt).
GB-A 1568856 and FR-A-2347049 relate to compositions for the treatment of the hair and suggest an extract of red squill including a scilleroside as the active ingredient.
(a) WO-A-91/04007 relates to a conditioning activator for a no-lye hair relaxer including a water-soluble cationic compound as a conditioning agent for the hair.
JP-A-2247299 relates to a neutral liquid cleanser composition for use with tableware which is also soft on the skin which comprises inter alia a water soluble salt which may be a sodium or potassium oxalate.
JP-A-2133208 relates to a method of modifying keratin fibre by applying thereto a water soluble substance which forms a water insoluble or slightly soluble salt on contact with keratin. This is a two-part composition, one part of which may be calcium oxalate. The so-treated keratin fibre is more durable.
JP-B-54006612 relates to a solution for removing permanent waves from the hair. The solution comprises inter alia a sodium or potassium oxalate, but is specifically for the reversal of a permanent wave that has been formed by a chelate-forming metal oxide method.
Finally, JP-A-59139313 relates to a hair treating composition to maintain the set of the hair, one of many components in this composition being sodium oxalate.
The applicant has now found that in neither of Canadian 888689 or GB-A-1568856 was the active principle defined. It was in fact an oxalate and particularly a group IA or IIa metal or ammonium oxalate. In the case of the first Canadian disclosure the active principle may in fact have been a ferrous oxalate salt but was not defined as such, and tests have shown that said ferrous salt was generally ineffective on its own. Similarlly in the second GB or FR disclosure the oxalate was not specifically mentioned as a component of red squill.
Accordingly the first aspect of the present invention provides a pharmaceutical composition for restoration of hair loss by topical administration to the scalp or skin which comprises a pharmaceutically acceptable oxalate of a Group Ia or IIa metal or ammonium oxalate or a tricologically active derivative thereof disposed in a topically applicable pharmaceutically acceptable carrier or diluent therefore.
The carrier or diluent may be aqueous and/or alcoholic and may include a viscous base to retain the composition in situ in use. A suitable diluent is water or an alcohol such as isopropanol and/or for propylene glycol to form a lotion. To form a cream
REFERENCES:
Abstract of JP-A-2-247299.
Abstract of JP-A-1-233208.
Abstract of JP-A-54-6612.
Abstract of JP-A-59-139313.
Abstract of JP-A-3-258713.
LandOfFree
Compositions for treatment of the hair does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for treatment of the hair, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for treatment of the hair will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2155919