Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1986-07-14
1988-05-03
Brown, J. R.
Drug, bio-affecting and body treating compositions
Lymphokine
424 98, 514825, 514885, 514903, 514907, A61K 3900, A61K 3558
Patent
active
047419024
ABSTRACT:
The invention provides compositions of matter having pharmacological activity and which are useful in the treatment of the symptoms of neurological and other disorders, particularly those disorders which are caused by malfunction of the immune mechanism. The present compositions include venoms and/or venom fractions extracted from various elapid and viperid snakes and generally include a postsynaptic component capable of binding to nicotinic acetylcholine receptors of cells, a presynaptic component capable of inhibition of acetylcholine release, and a viperid component stimulative of the immune system. According to the present invention, the viperid component of the present compositions of matter preferably constitutes a venom fraction which is absent certain enzymes such as L-amino acid oxidase and phosphodiesterase, these compositions being of particular utility due to the absence of a hemorrhagic effect when used in the treatment of mammals. Methods of preparation and use of the present compositions of matter are also disclosed.
REFERENCES:
patent: 4126676 (1978-11-01), Sanders
patent: 4341762 (1982-07-01), Haast
Brown J. R.
Darnell Kenneth E.
Rollins John W.
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