Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-12-20
1986-10-28
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31535
Patent
active
046199284
ABSTRACT:
The invention involves compositions useful for treating certain malignant tumors with the compound ethyl 4-hydroxy-2-[(5-morpholinomethyl-2-oxo)-3-oxazolidinyliminomethyl]furo[2,3 -b]pyridine-5-carboxylate (Compound I) or its pharmaceutically acceptable salts or hydrates.
REFERENCES:
Snyder and Ebetino, "A New Synthesis of Furo[2,3-b]Pyridine Derivatives (1)", The Journal of Heterocyclic Chemistry, vol. 3 (1966), pp. 202-205.
Manske and Holmes, "III. The Furoquinoline Group," The Alkaloids, vol. III, Academic Press, Inc., New York, N.Y. (1953), pp. 69-71.
Ebetino et al., "Reduction of Nitrofurans. I. Aminofurans," J. Med. Pharm. Chem., vol. 5 (1962), pp. 513-524.
Paul et al., "Metabolism of the Nitrofurans. I. Ultraviolet Absorption Studies of Urinary End-Products After Oral Administration", J. Biol. Chem., vol. 180 (1949), pp. 345-363.
Bender and Paul, "Metabolism of the Nitrofurans. II. Incubation of Furacin with Mammalian Tissues," J. Biol. Chem., vol. 191 (1951) pp. 217-222.
Taylor et al., "Metabolism of the Nitrofurans. III. Studies with Xanthine Oxidase in Vitro," J. Biol. Chem., vol. 191 (1951) pp. 223-231.
Paul et al., "Metabolic Degradation of the Nitrofurans," J. Med. Pharm. Chem., vol. 2 (1960) pp. 563-584.
Olivard et al., "The Metabolism of 5-Nitro-2-Furaldehyde Acetylhydrazone," J. Med. Pharm. Chem., vol. 5 (1962) pp. 524-531.
Beckett and Robinson, "The Reactions of Nitrofurans with Bacteria-II.", J. Med. Pharm. Chem., vol. 1 (1959) pp. 135-154.
Beckett and Robinson, "The Reaction of Nitrofurans with Bacteria-III", J. Med. Pharm. Chem., vol. 1 (1959) pp. 155-164.
Chemical Abstracts 65:5435h (1966) along with the index which set forth the compound.
Burch Homer A.
Ebetino Frank F.
Goldberg Jerome D.
Goldstein Steven J.
Graff IV Milton B.
Norwich Eaton Pharmaceuticals, Inc.
Zerby Kim William
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