Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1998-05-13
1999-12-07
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
514252, A61K 3159, A61K 31495
Patent
active
059983949
ABSTRACT:
Described are in vivo methods for testing the activity of vitamin D.sub.3 (1,25-dihydroxyvitamin D.sub.3) and analogs thereof in human skin and for testing the effect of a test compound on said activity. Also described are methods for enhancing the in vivo activity of vitamin D.sub.3 and analogs thereof by coadministering vitamin D.sub.3 or an analog thereof with an RXR ligand, a 24-hydroxylase inhibitor, or a mixture thereof. Preferred RXR ligand materials are retinoids, such as 9-cis retinoic acid, and precursors thereof, such as all trans retinoic acid. Preferred 24-hydroxylase inhibitors are imidazoles, especially those inhibiting cytochrome-P450 oxidative enzymes, such as ketoconazole. Also included is a method for determining whether a candidate compound inhibits 24-hydroxylase activity or induction thereof.
REFERENCES:
patent: 4569935 (1986-02-01), Rosenberg et al.
Spearman et al., Brit. J. Dermatology, 40(5) 553-60 (abstract), 1974.
Lutzow-Horn et al., Experimental Dermatology 2(3), 113-20 (Denmark) (abstract), 1993.
Cauwenbergh Geert
Kang Sewon
Voorhees John J.
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