Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Skin cosmetic coating
Patent
1996-02-12
1997-12-30
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Skin cosmetic coating
424 62, 424 69, 424240, 514861, 514 24, 514771, 514863, 514887, A61K 7135, A61K 3134, A01N 4304, A01N 2500
Patent
active
057026947
DESCRIPTION:
BRIEF SUMMARY
BRIEF SUMMARY OF THE INVENTION
The invention relates to topical compositions for treating corns, calluses, and warts which comprise a benzenediol. Included among benzenediols are benzenediols or substituted benzenediols selected from the group consisting of hydroquinone, olivetol, pyrocatechol, 2,5-dihydroxy benzoic acid; or 1,2-benzenediols substituted in the 4-position selected from the group consisting of nordihydroguaiaretic acid (NDGA) and 4-nitrocatechol, in combination with a pharmaceutically acceptable carrier. The invention also relates to a method for treating the above-described conditions which comprises administering an effective amount of a benzenediol or substituted benzenediol selected from the group consisting of hydroquinone, olivetol, pyrocatechol, and 2,5-dihydroxy benzoic acid or 1,2-benzenediols substituted, for example, on the 4-position, such as nordihydroguaiaretic acid (NDGA) and 4-nitrocatechol.
DETAILED DESCRIPTION OF THE INVENTION
Hyperkeratotic tissues, such as: corns (heloma), calluses (tyloma) and warts (condyloma), are well defined, thickened lesions of the epidermis. They occur at skin sites that are normally involved in chronic mechanical stress (corns and calluses) or infected with papilloma virus (warts). Pain produced by the thickened tissue can cause these lesions to be debilitating.
Traditionally, "keratolytic agents", such as: salicylic acid and resorcinol, have been applied topically to these lesions to solubilize intercellular bonds resulting in desquamation of the thickened, hyperkeratotic tissues.
The goal was to develop a faster acting corn and callus remover product. To achieve this goal benzenediols were evaluated. Assays of keratinocyte differentiation and keratolytic action, as described below were employed to identify the compounds that possess this activity.
As used herein, "alkyl" means a straight or branched chain alkyl group. Alternatively, the number of carbon atoms in a particular alkyl group may be specified. For example, C.sub.1 -C.sub.8 alkyl, refers to a straight or branched chain alkyl group having one to eight carbon atoms. Halo refers to chloro, bromo, iodo, and fluoro.
The present invention provides new topical compositions for the treatment of all kinds of corns, calluses, or warts. The compositions of the invention provide for faster removal of corns, calluses, and warts than do prior art compositions. The compositions of the invention can also be used in the treatment of hyperkeratinizing and hyperproliferative skin diseases and conditions such as ichthyoses, porokeratoses, follicular keratoses, palmoplantar keratodermas, psoriasis, eczema, dandruff and dry skin. The invention also relates to a method for treating the above-described medical conditions which comprises administering an effective amount of a benzenediol or substituted benzenediol selected from the group consisting of hydroquinone, olivetol, pyrocatechol, 2,5-dihydroxy benzoic acid; or a 1,2-benzenediol substituted in the 4-position selected from the group consisting of nordihydroguaiaretic acid (NDGA) and 4-nitrocatechol.
The topical compositions of the present invention comprise a benzenediol. As used herein, "benzenediol" means the following: a benzenediol or a substituted benzenediol. Among substituted benzenediols are dihydroxyphenylalkyl benzenediols. Exemplary of benzenediols and substituted benzenediols are compounds such as hydroquinone, olivetol, pyrocatechol, 2,5-dihydroxy benzoic acid; or a 1,2-benzenediol substituted, for example, in the 4-position. More specifically, the substituents which can occur in the 4-position or in other positions on the benzene in the compounds of the invention are nitro, halo, C.sub.1 -C.sub.8 alkyl, or dihydroxyphenyl-C.sub.1 -C.sub.8 alkyl-. Specific 1,2-benzenediols substituted in the 4-position include nordihydroguaiaretic acid (NDGA) and 4-nitrocatechol.
A preferred benzenediol of the invention is pyrocatechol.
Pyrocatechol is a 1,2-benzenediol. The chemical structure of pyrocatechol is as follows: ##STR1##
Pyrocatechol is a c
REFERENCES:
patent: 3856934 (1974-12-01), Kligman
patent: 4568539 (1986-02-01), Ashton et al.
patent: 4694021 (1987-09-01), Schweiger
patent: 5310730 (1994-05-01), Fujinuma et al.
Patent Abstracts of Japan, vol. 11, No. 251, (C-440) and JP,A, 62 056 411, "Beautifying Agent" (Suzuki Yumiko et al (abstract), 12 Mar. 1987, Japan.
Database WPI Week 8539, Derwent Publications Ltd., London GB 85-239345 and JP,A,60 155 111 (Hisamitsu Pharm KK) (abstract), 15 Aug. 1985, Great Britain, Japan.
Journal of the American College of Toxicology, vol. 5, No. 3, 1986, pp. 123-165.
CA 116(3): 15811c, "Methods of Treating Tumors With Compositions of Catecholic Butanes. . ." (1991).
CA Abstract #91: 9505e of Belgium 871, 192 (1979) Knood Henri.
CA Abstract #113: 178100 of Teikyo Igakac Zosshi (1990), 13(1), 33-41; Nishitani, et al.
Callus and Wart Remover, vol. 91, 1979.
Boxer Matthew
Maitner John
Page Thurman K.
Schering-Plough Healthcare Products Inc.
Shelborne Kathryne E.
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