Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1996-05-28
1998-05-12
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
424685, 424711, 514 23, 514 25, 514574, 514882, A61K 3304, A61K 3306, A61K 3310, A61K 3170
Patent
active
057501505
ABSTRACT:
Injectable compositions for treating affected tissues are prepared by formulating sodium hydrogen sulfite with all other components except tannic acid to yield a first mixture and adding tannic acid to the first mixture, or, by formulating a water-soluble aluminum compound and a chelating agent to yield a first formulation, formulating tannic acid and sodium hydrogen sulfite to yield a second formulation and admixing the first formulation with the second formulation to yield a second mixture and, as needed, adding a polyvalent alcohol and/or a saccharide to the first and/or second formulations or to the first or second mixture, thereby formulating the injectable composition having a pH range of from pH 1.0 to pH 3.5. This preparation can prevent the oxidation of tannic acid and the direct reaction with aluminum ions derived from sodium hydrogen sulfite, whereby the composition can provide a stable formulation as well as ensure effectiveness as an injectable preparation in a solution form.
REFERENCES:
patent: 5252344 (1993-10-01), Shi
"Aluminum Potassium Sulfate", Commentary on Pharmacopedia Japonica, 12th Revision, 1991, pp. D-1019-1021, with translation.
Yuan, et al., "Experimental Study of Xiaozhiling injection", Journal of Traditional Chinese Medicine, vol. 1, No. 2, 1981, pp. 87 and 116.
Okazaki Hideo
Oku Kinuko
Spivack Phyllis G.
Traditional Chinese Medicine Research Laboratory, Inc.
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