Compositions for topical application to skin, hair and nails

Details Compositions for topical application to skin, hair and nails Compositions for topical application to skin, hair and nails

1994-10-21

1995-12-19

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 61, 424701, 514844, 514846, 514847, A61K 748, A61K 706, A61K 704

Patent

active

054766613

ABSTRACT:
Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.

REFERENCES:
patent: 4778823 (1988-10-01), Kawamata et al.
patent: 4985547 (1991-01-01), Yano et al.
patent: 5175321 (1992-12-01), Ohashi et al.
patent: 5198210 (1993-03-01), Critchley et al.
patent: 5206020 (1993-04-01), Critchley et al.
Pillai et al., "Epidermal Vitamin D Metabolism, Function, and Regulation", Advances In Lipid Research, vol. 24, (1991), pp. 321-341.
Bikle et al., "1,25-Dihydroxyvitamin D.sub.3 Production by Human Keratinocytes", The Journal of Clinical Investigation, Inc., vol. 78, (Aug. 1986), pp. 557-566.
Pillai et al., "1,25-Dihydroxyvitamin D Production and Receptor Binding in Human Keratinocytes Varies with Differentiation", The Journal of Biological Chemistry, vol. 263, No. 11, (Apr. 15, 1988), pp. 5390-5395.
Hashimoto et al., "Growth-inhibitory Effects of 1,25-Dihydroxyvitamin D.sub.3 on Normal and Psoriatic Keratinocytes", British Journal of Dermatology, (1990), vol. 123, pp. 93-98.
Morimoto et al., "Topical Administration of 1,25-Dihydroxyvitamin D.sub.3 for Psoriasis: Report of Five Cases", Calcif Tissue Int., vol. 38, (1986), pp. 119-122.
MacLaughlin et al., "Cultured Human Keratinocyctes Cannot Metabolize Vitamin D.sub.3 to 25-hydroxyvitamin D.sub.3 ", Federation of European Biochemical Societies, vol. 282, No. 2, (May 1991), pp. 409-411.
Holick, M. F. in "Cutaneous Aging" (edited by A. Kligman), pp. 223-246, Univ. of Tokyo Press, Tokyo, 1988.
Bikle et al., "Squamous Carcinoma Cell Lines Produce 1,25-Dihydroxyvitamin D, but Fail to Respond to Its Prodifferentiating Effect", The Society for Investigative Dermatology, Inc., (1991), p. 435.
Okazaki et al., reported in "Role of Ceramide as a Lipid Mediator of 1.alpha.,25-Dihydroxyvitamin D.sub.3 -induced HL-60 Cell Differentiation", The Journal of Biological Chemistry, vol. 265, No. 26, Sep. 15, 1990, pp. 15823-15831.
Calcif Tissue Int, vol. 38 pp. 119-122 (1986).

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