Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride
Patent
1998-01-21
2000-12-12
Pak, Joh
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Alkali or alkaline earth chloride
4241951, 424466, 424601, 424602, 424630, 424637, 424639, 424641, 424646, 424665, 424670, 424682, 424683, 424686, 424688, 424689, 424692, 424697, 424717, 424722, 514 52, 514165, 514249, 514251, 514276, 514345, 514355, 514387, 514419, 514456, 514457, 514458, 514464, 514474, 514563, 514570, 514574, 514629, 514630, 514904, 514905, A61K 3300, A61K 3306, A61K 3308, A61K 3310, A61K 3312, A61K 3314, A61K 314415
Patent
active
061595055
DESCRIPTION:
BRIEF SUMMARY
FIELD OF INVENTION
This invention relates to novel treatments for migraine which the inventor believes is triggered by a stress reaction.
BACKGROUND
At the onset of the stress reaction the pituitary gland (triggered by the hypothalamus) initiates protective action by secreting the adrenocorticotropic hormone ACTH.
This hormone is transported in the blood to the adrenal glands, which immediately respond to deal with this stress emergency signal, by producing cortisol and aldosterone.
Under non-stress conditions the adrenal glands utilise certain vitamins and minerals in order to function. In order to respond to stress they need an increased supply of vitamins and minerals. These additional supplies are rapidly used up in the stress response reaction. Therefore the adrenal glands ability to resist stress is dependent upon the supply of these "activator" nutrients. If stress is prolonged, or chronic, ultimately the adrenal glands will exhaust themselves through the lack of readily available activator nutrients. Some nutrients are particularly susceptible to depletion.
Vitamin B.sub.6 (pyridoxine) is needed by the adrenals and in protein synthesis and in manufacture of vitamin B.sub.3. If used in quantity to manufacture B.sub.3 to counteract stress, less is available to the adrenals or for protein synthesis. Additional supplies of vitamin B.sub.6 are "stolen" from any available sources to answer stress demands. As another part of the stress response mechanism, intracellular potassium, lost from the body in the urine in response to aldosterone, is replaced by potassium held in store within the muscle tissues and bones. There is an overall potassium depletion. Cortisol, produced with aldosterone during the stress reaction, requires a range of nutrients to exert its effects, but particularly vitamin B.sub.6 and potassium. Histamine may be produced as a consequence of the stress response. Histamine production can be one of the features of a migraine attack.
As a result of sustained stress, the blood sugar level rises markedly to meet the immediate need but then may drop significantly as a condition of adrenal exhaustion is precipitated. At this point cortisol ceases to rapidly stimulate conversion of protein into sugar and cannot keep pace with the stress induced sugar demands. This may result in hypoglycaemia which also may be a feature of migraine attacks.
As a further stress response, aldosterone is also secreted by the adrenal glands in abnormally large amounts. This immediately triggers the kidneys to retain salt and water while losing potassium.
Consequences of this process may be an elevation of the blood pressure and the expulsion of intracellular potassium. This loss of potassium from cells may cause many adverse consequences since all tissues of the body, especially muscles and nerves, require a normal cellular potassium balance. The sodium retention and potassium loss may cause elevation of blood pressure and acidosis which also can be features of a migraine attack. The potassium loss may be particularly important.
The body relies upon vitamins and minerals for the efficient functioning of the nervous system. Many act in a synergistic mode and cannot function fully without the help of other contributory elements. A lack of one affects all.
A number of vitamins and minerals play multiple roles in the stress response and act in concert to deal with stress. For example, vitamin B.sub.5 and vitamin C which may be used to help counteract stress, are also prime activators of the adrenal glands. Vitamin B.sub.6 is vital for the nervous system, and essential to the adrenal glands. The B vitamins are synergistic and all may need to be given in order to be fully functional. Vitamin C requires bioflavonoids for optimum efficiency.
Furthermore, in order to exert many of its functions, vitamin B.sub.6 requires the presence of the mineral magnesium. Magnesium is also essential to normal adrenal gland function. Magnesium can be an anti-stress nutrient, capable of reducing aldosterone production, thereby preventing
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