Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-01-07
2000-06-13
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514764, 514765, 514396, 514880, 514881, A61K 31555, A61K 31015, A61K 31415
Patent
active
060750170
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The invention relates to pharmaceutical compositions for use in the treatment of seborrheic dermatitis of the scalp.
BACKGROUND OF THE INVENTION
Dandruff, seborrheic dermatitis of the scalp, is a common disease involving 3-5% of the population. Dandruff is, in many cases, the precursor of alopecia (baldness) and constitutes a chronic and almost intractable cosmetical and social inconvenience. The pathophysiology of the disease remains unknown, although it is known to involve a hyperproliferative state of the skin, a limited inflammatory process, and a secondary microbial colonization by the lipophilic yeast Pityrosporum, which is abundant and significantly overpopulated on the scalp of seborrheic patients.
Dandruff is a chronic and almost incurable disease. Available treatments result only in short term effects with an eventual recurrence of the disease.
A traditional treatment of dandruff included administration onto the scalp of either a cytotoxic agent or an antifungal agent. However, as pointed out heretofore no treatment provides long term alleviation from the symptoms of this disease.
It is an object of the invention to provide a composition useful in the treatment of dandruff or symptoms associated therewith.
It is another object of the invention to provide a method for alleviation of dandruff or symptoms associated therewith.
GENERAL DESCRIPTION OF THE INVENTION
The present invention provides by a first of its aspects a composition, e.g. in the form of a hair shampoo, for the treatment of dandruff or of symptoms associated therewith, comprising in combination an effective amount of at least one cytotoxic agent and an effective amount of at least one antifungal agent, together with a carrier, a diluent or an excipient.
The term "effective amount" as used herein means to denote an amount of an agent effective in achieving a therapeutic result in the treatment of dandruff, such as alleviation of itching, a decrease in the amount of scales, a reduction in the rate of hair loss, a reduction in scalp redness, etc.
The term "cytotoxic agent" as used herein means to denote an agent which inhibits proliferation of keratinocytes skin cells. The term "antifungal agent" will be used to denote an agent which is specifically active in inhibiting growth of fungus and the fungus' ability to colonize the skin, which includes, intei alia, agents which are destructive to fungi, or active in suppressing growth of fungus or affect their ability to reproduce.
It will be appreciated by the artisan that the agents which are cytotoxic may also have some anti-fungal activity and an anti-fungal agent may also have somc cytotoxic activity. Thus, the term "cytotoxic agent" refers to agents which are known in the art primarily by having cytotoxic activity and the term "antifungal agent" refers to agents which are known in the art primarily by their antifungal activity.
In the following description reference will at times be made to concentrations given in percent (%), this indication meaning the number of weight units of any ingredient in hundred weight units of an entire composition.
Examples of cytotoxic agents useful in accordance with the invention are coal tars, zinc pyrithione or the like. The preferred cytoxic agent is coal tar, typically included in the composition in concentration of 1-5%.
Examples of antifungal agents useful in accordance with the invention include imidazoles, ciclopiroxolamines and metronidazoles. The imidazoles, which are preferred in accordance with the invention, include ketoconozole, bifonazole, itraconazole, econazole, clotrimazole, miconazole, oxiconazole, isoconazole and the like. From the imidazoles, ketoconozole is particularly preferred. Typically, the antifungal agent is included in the composition in a concentration of 0.5-5%.
The present invention further provides the use of said cytotoxic agent in combination with said antifungal agent for the preparation of a composition, e.g. a medical hair shampoo, for the treatment of dandruff.
A further aspect of the i
REFERENCES:
patent: 4294852 (1981-10-01), Wildnauer et al.
patent: 4491588 (1985-01-01), Rosenburg et al.
patent: 4518789 (1985-05-01), Yu et al.
CA 122: 248020, Cid, et al, Dec. 01, 1994.
CA 119: 15355, Mason et al, Apr. 29, 1993.
Blosis AN 91: 234987, McGrath, 1991.
CA 120: 212389, Wright et al, 1993.
Merck Index 10 edition, # 2374, # 6033, 1983.
Remingtons Pharmaceutical Sciences, p. 725, 1975.
Dascalu Avi
Oron Yoram
Cook Rebecca
Ramot University Authority for Applied Research and Industrial
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