Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-12-14
2000-05-02
Yucel, Remy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
530350, 530351, C12Q 168
Patent
active
060571098
ABSTRACT:
The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.
REFERENCES:
patent: 4190496 (1980-02-01), Rubenstein
patent: 5093246 (1992-03-01), Cech et al.
Astrup A. et al., 1989, "Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle", Am. J. Physiol. 257:E340-E345.
Been and Cech, 1986, "One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity", Cell, 47:207-216.
Bhandari et al., 1991, "A functional promoter flanks an intronless glutamine synthetase gene", J. Biol. Chem. 266:7784-7792.
Bibb et al., 1981, "Sequence and gene organization of mouse mitochondrial DNA", Cell 26:167-180.
Block BA., 1994, "Thermogenesis in muscle", Ann. Rev. Physiol. 56:535-577.
Borjeson, M., 1976, "The aetiology of obesity in children. A study of 101 twin pairs", Acta. Paediatr. Scand. 65:279-287.
Bouillaud F. et al., 1994, "A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein", EMBO J. 13:1990-1997.
Cannon & Nedergaard, 1985, "The biochemistry of an inefficient tissue: brown adipose tissue", Essays in Biochem. 20:110-165.
Cassard AM. et al., 1990, "Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4", J. Cell Biochem. 43:255-64.
Coleman, D.L., and Eicher, E.M., 1990, "Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse", J. Heredity 81:424-427.
Coleman, D.L., 1978, "Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice", Diabetologia 14:141-148.
Cummings D.E. et al., 1996, "Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A", Nature 382:622-626.
Cunningham S. et al., 1985, "The characterization and energetic potential of brown adipose tissue in man", Clin. Sci. 69:343-348.
Davis T.R.A., 1963, "Contribution of skeletal muscle to non-shivering thermogenesis in the dog", Am. J. Physiol. 213:1423-1426.
Duchamp C. et al., 1993, "Skeletal muscle as the major site of non-shivering thermogenesis in cold-acclimated ducklings", Am. J. Physiol. 265:R1076-R1083.
Esner, M., 1979, "The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese-hyperglycemic (ob/ob) and lean mice", Biochem. J. 180:551-558.
Flier et al., 1987, "Severely impaired adipslin expression in genetic and acquired obesity", Science 237:405-408.
Flower, D.R. et al., 1991, "Mouse oncogene protein 24p3 is a member of the lipocalin protein family", Biochem. Biophys. Res. Comm. 180:69-74.
Forman et al., 1994, "Cross-talk amoung ROR.alpha.1 and the rev-erb family of orphan nuclear receptors", Mol. Endocrinol. 8:1253-1261.
Friedman, J.M. et al., 1991, "Molecular mapping of obesity genes", Mammalian Gene 1:130-144.
Genbank Accession No. L00993, 1993.
Genbank Accession No. P16036, 1996.
Genbank Accession No. P12242, 1997.
Gonzalez-Barioso MM. et al., 1996, "Activation of the uncoupling protein by fatty acids is modulated by mutations in the C-terminal region of the protein", Eur. J. Biochem. 239:445-450.
Hamann et al., 1996, "Decreased brown fat markedly enhances susceptibility to diet induced obesity, diabetes, and hyperlipidemia", Endocrinol. 137:21-29.
Haseloff and Gerlach, 1988, "Simple RNA enzymes with new and highly specific endoribonuclease", Nature, 334:585-591.
Herberg, L. and Coleman, D.L., 1977, "Laboratory animals exhibiting obesity and diabetes syndromes", Metabolism 26:59-99.
Himms-Hagen J., 1989, "Brown adipose tissue thermogenesis and obesity", Prog. Lipid Res. 28:67-115.
Hou, J. et al., 1994, "Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HEPG2)", In Vitro Cell. Dev. Biol. Anim. 30A:111-114.
Houghten, R. et al., 1991, "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery", Nature 354:84-86.
Hraba-Renevey, S. et al., 1989, "SV40 induced expression of mouse gene 24p3 involves a posttranscritional mechanism", Oncogene 4:601-608.
Huttunen P. et al., 1981, "The occurrence of brown adipose tissue in outdoor workers", Eur. J. Appl. Physiol. 46:339-345.
Jensen M.D. et al., 1995, "Thermogenesis after a mixed meal: role of leg and splanchnic tissues in men and women", Am. J. Physiol. 268:E433-438.
Kaestner, K.H. et al., 1989, "Differentiation-induced gene expression in 3T3-L1 preadipocytes", J. Biol. Chem. 264:14755-14761.
Klaus S. et al., 1991, "The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue", Int. J. Biochem. 23:791-801.
Klingenberg M., 1990, "Mechanism and evolution of uncoupling protein of brown adipose tissue", Trends Biochem. Sci. 15:108-112.
Kopecky J. et al., 1995, "Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity", J. Clin. Invest. 96:2914-2923.
Kouba, M. et al., 1993, "Liver stearyl-coA desaturase activity and fatness in birds. In vitro studies in the growing turkey and chicken", Comp. Biochem. Physiol. 105A:359-362.
Kuan & Saler, 1993, "The mitochondrial carrier family of transport proteins: structural, functional, evolutionary relationships", Crit. Rev. Biochem. Mol. Biol. 18:209-233, 1993.
Lam et al., 1991, "A new type of synthetic peptide library for identifying ligand binding activity", Nature 354:82-84.
Legrand, P. et al., 1987, "Hepatic lipogenesis in genetically lean and fat chickens in vitro studies", Comp. Biochem. Physiol. 87B:789-792.
Lowell, 1990, "Reduced adipsin expression in urine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine", Endocrinology 126:1514-1520.
Lowell B.B. et al., 1993, "Development of obesity in transgenic mice after genetic ablation of brown adipose tissue", Nature 366:740-742.
Matsunaga, E. et al., 1990, "The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450", J. Mol. Evol. 30:155-169.
McFarlane-Anderson, 1992, "Levels of G-proteins in liver and brain of lean and obese (ob/ob) mice", Biochem. J. 282:15-23.
Moll et al. 1991, "The genetic and environmental sources of body mass index variability: the muscatine ponderosity family study", Am. J. Hum. Gen. 49:1243-1255.
Murdza-Inglis, D.L. et al., 1994, "A single mutation in uncoupling protein of rat brown adipose tissue mitochondria abolishes GDP sensitivity H.sup.+ transport", J. Biol. Chem. 269:7435-7438.
Murdza-Inglis, D.L. et al., 1991, "Functional reconstitution of rat uncoulpling protein following its high level expression in yeast", J. Biol. Chem. 260:11871-11875.
Myers & Miller, 1988, "Optimal alignments in liner space", CABIOS 4:11-17.
Nicholls & Locke, 1984, "Thermogenic mechanisms in brown fat", Physiol. Rev. 64:1-64.
Ntambi, J.M. et al., 1988, "Differentiation-induced gene expression in 3T3-L1 preadipocytes", J. Biol. Chem. 263:1
Millennium Pharmaceuticals Inc.
Yucel Remy
LandOfFree
Compositions for the treatment of body weight disorders includin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for the treatment of body weight disorders includin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for the treatment of body weight disorders includin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1592742