Compositions for the treatment of acne containing a derivative o

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424401, 424 62, 424 63, 4284022, A61K 9127

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active

054117429

ABSTRACT:
Composition for the treatment of acne containing a dispersion of vesicles of ionic or non-ionic amphiphilic lipids, the vesicles containing in the lipid phase at least one salicylic acid derivative of formula (I): ##STR1## in which R represents a linear or branched C.sub.11 -C.sub.17 alkyl radical; R'.sub.1, R'.sub.2, R'.sub.3, which are identical or different, represent a C.sub.1 -C.sub.18 alkyl or hydroxyalkyl radical, it being possible for one of the radicals R'.sub.1, R'.sub.2 or R'.sub.3 to be a benzyl radical. The derivative of formula (I) serves both as charged lipid and as anti-acne active ingredient. The derivatives of formula (I) in which, when R represents a C.sub.13 -C.sub.17 alkyl radical, R'.sub.1, R'.sub.2, R'.sub.3, when they are identical, do not represent a hydroxyethyl radical.

REFERENCES:
patent: 4897308 (1990-01-01), Vanlabughe
patent: 5001156 (1991-03-01), Philippe et al.
patent: 5019567 (1991-05-01), Philippe

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