Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound
Reexamination Certificate
2005-03-15
2005-03-15
Pak, John (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Sulfur, selenium or tellurium compound
C514S858000, C514S859000, C514S860000, C514S861000, C514S862000, C514S863000, C514S864000, C514S865000, C514S887000
Reexamination Certificate
active
06867238
ABSTRACT:
Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating organic selenium compounds in combination with inert carriers in therapeutically effective amounts of selenium compound. The selenium compounds are medium linear chain dialkyl diselenides and precursors such as alkyl selenols. Preferred compositions employ R—Se—Se—R compounds where R is from 6 to 8 carbon atoms, and most specifically di-n-hexyl diselenide. Commonly used carriers may be purified hydrocarbon fractions, oils, with or without added fat-soluble vitamins, water and emulsifying agents.
REFERENCES:
patent: 4512977 (1985-04-01), Lundy
patent: 4865840 (1989-09-01), Burke et al.
patent: 3408362 (1983-03-01), None
patent: 4320694 (1995-01-01), None
Easaki, N. et al., “Catalytic action of L-methionine γ-lyase on selenomethionine and selenols,” Biochemistry, vol. 18(3), 1979, pp. 407-410.*
G. Scambia et al.; “Growth Inhibitory Effect of Diheptyl Diselenide on Various Human Cancer Cell Lines”; Anticancer Research vol. 9, pp. 1967-1700 (1989).
Christie Parker & Hale LLP
Pak John
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