Compositions for the introduction of polyanionic materials into

Details Compositions for the introduction of polyanionic materials into Compositions for the introduction of polyanionic materials into

1995-05-16

1998-05-19

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514 43, 514 44, 424450, A61K 3722, C07H 2102, C07H 2104

Patent

active

057536139

ABSTRACT:
The present invention provides compositions and methods which are useful for the introduction of polyanionic materials into cells. The compositions are mixtures of cationic compounds and neutral lipids which are typically formulated as liposomes. The cationic compounds are quaternary ammonium compounds wherein the nitrogen has two attached long chain alkyl groups, at least one of which is unsaturated. The methods for transfecting cells involve (a) contacting the polyanionic materials with the compositions above to form a polyanionic material-liposome complex, and (b) contacting the complex with the cells to be transfected.

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